PMID: 8974061Oct 1, 1996Paper

The effect of insulin-like growth factor-1 on adult rat cardiac contractility

Molecular and Cellular Biochemistry
N S FreestoneW T Mason

Abstract

There is increasing evidence that insulin-like growth factor-1 (IGF-1) may play a role in both physiological and pathophysiological events in the mammalian myocardium. The present study investigated the acute effects of IGF-1 on isometric force development in isolated rat cardiac muscle and on intracellular calcium (Ca2+) handling in isolated cardiac myocytes. IGF-1 had a positive inotropic effect on rat ventricular papillary muscles increasing force development by 17.8 +/- 4.6%, 18.5 +/- 5.8% and 11.9 +/- 4.9% (n = 12-20) at concentrations of 1, 10 and 100 ng/ml respectively. Isoprenaline increased tension in these papillary muscles by 56.7 +/- 7.7% at a concentration of 100 nM (n = 22). In comparison, insulin increased papillary muscle force development by 11.6 +/- 3.2%, 17.7 +/- 4.1% and 19.7 +/- 5.6% at concentrations of 1, 10 and 100 nM respectively (n = 16-20). In the single cardiac myocyte IGF-1 increased, the peak cytosolic free Ca2+ concentration, the amplitude of the Ca2+ transient and the time to peak Ca2+ as measured with the fluorescent bioprobe Indo-1 AM. The positive inotropic response to IGF-1 by rat ventricular muscle is therefore associated with a rise in free, peak cytosolic Ca2+ in isolated cardiac myocytes....Continue Reading

References

May 1, 1976·The American Journal of Physiology·J C Lee, S E Downing
Feb 15, 1992·The Biochemical Journal·S J FullerP H Sugden
Sep 1, 1987·Journal of Cardiovascular Pharmacology·M P GuptaN S Dhalla
Jan 1, 1985·Annual Review of Physiology·E R FroeschJ Zapf
Jul 1, 1988·Journal of Molecular and Cellular Cardiology·S E HardingP A Poole-Wilson
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L S MathewsR D Palmiter
Jan 1, 1987·Acta Physiologica Scandinavica·E JennischeH A Hansson
Jul 1, 1973·The Journal of Physiology·R D Moore
Apr 1, 1972·European Journal of Pharmacology·B R LucchesiF J Kniffen
Mar 1, 1984·The American Journal of Physiology·R L DeHaanL J Elsas
Feb 6, 1981·Biochimica Et Biophysica Acta·K Zierler, E M Rogus
Dec 1, 1993·Genes & Development·L Powell-BraxtonT A Stewart

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Citations

Jun 29, 2005·Treatments in Endocrinology·Annamaria ColaoGaetano Lombardi
Oct 19, 2006·Neuroendocrinology·Gaetano LombardiAnnamaria Colao
May 9, 2008·Clinical Endocrinology·Annamaria Colao
Jan 7, 2010·Journal of Cardiovascular Pharmacology·Fernanda D OleaAlberto Crottogini
Aug 19, 2000·American Journal of Physiology. Endocrinology and Metabolism·M F AllardG P Bondy
Apr 4, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Massimiliano GnecchiVictor J Dzau
Jun 19, 2012·Clinical Endocrinology·Gilvan Cortês NascimentoManuel dos Santos Faria
Feb 24, 2001·Clinical Endocrinology·A ColaoG Lombardi
Apr 8, 1999·Journal of Applied Physiology·L P KozirisT G Unterman
Sep 5, 2001·The Journal of Physiology·J ChenS L Britton
Aug 28, 2004·Treatments in Endocrinology·Giovanni VitaleAnnamaria Colao
May 29, 2009·Journal of Lipid Research·Jing YanFrank J Burczynski
Jul 4, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Lei WangGanghong Tian
Jun 26, 2014·Journal of Veterinary Internal Medicine·J A MyersJ M Bright
Jul 28, 2016·European Journal of Clinical Investigation·Anna S E KoegelenbergAletta E Schutte
Apr 2, 2019·Frontiers in Endocrinology·Ana M Ramos-Leví, Mónica Marazuela
Feb 11, 2004·Endocrine Reviews·Annamaria ColaoGaetano Lombardi
Feb 1, 2007·Molecular and Cellular Biochemistry·YeQing PiJosé Marín-García
Jun 29, 2014·Endocrine·Jörgen IsgaardAntonio Cittadini
Nov 26, 2008·Circulation Research·Massimiliano GnecchiVictor J Dzau
Jan 4, 2017·Endocrine·Ana M Ramos-Leví, Mónica Marazuela
Feb 11, 1999·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A A ButlerD LeRoith
Jan 16, 1999·Journal of the American Society of Nephrology : JASN·D P QingJ D Kopple
Jul 9, 2021·Acta Cardiologica·Suleyman Nahit SendurTomris Erbas

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