The effect of insulin on aromatase activity in isolated human endometrial glands and stroma

American Journal of Obstetrics and Gynecology
J F RandolphK M Menon

Abstract

Hyperinsulinemic states have been associated with an increased incidence of estrogen-dependent endometrial neoplasia. To study the effect of insulin on the ability of endometrium to aromatize androgens to estrogens, late proliferative endometrium was obtained from normally cycling women at the time of indicated surgery, separated into component glands and stroma, and grown to confluence. Separated gland and stromal cultures were incubated in triplicate with increasing insulin concentrations and epidermal growth factor. Aromatase activity was assayed by the production of tritiated water from tritium-labeled androstenedione. The activity was noted to increase proportionally with increasing concentrations of insulin greater than 10 U/ml, and the effect was specific. These data suggest the following conclusions: (1) Insulin stimulates aromatase activity in both endometrial glands and stroma; (2) hyperinsulinemia may predispose to endometrial neoplasia by enhancing endogenous endometrial estrogen production.

References

Apr 1, 1979·The Journal of Clinical Endocrinology and Metabolism·P G SatyaswaroopE Gurpide
Sep 1, 1985·American Journal of Obstetrics and Gynecology·E E SheetsW N Spellacy
Nov 1, 1982·The Journal of Clinical Endocrinology and Metabolism·L TsengJ Chumas

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Citations

Jun 5, 2003·Lancet·Paul HardimanWilliam Atiomo
Aug 24, 2004·Journal of Cancer Research and Clinical Oncology·L M BersteinJ H H Thijssen
Sep 8, 2009·Journal of Pediatric and Adolescent Gynecology·Bina ShahRaphael David
Jun 15, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·Linda C Giudice
Aug 15, 1998·American Journal of Obstetrics and Gynecology·M Nagamani, C A Stuart
Jan 16, 1995·The American Journal of Medicine·M Gibson
Mar 19, 2002·Human Fertility : Journal of the British Fertility Society·Robert Fox, Audrey Ryan
Jul 16, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Angiolo GadducciAndrea Riccardo Genazzani
Oct 1, 1989·Clinical Endocrinology·M J Reed, V H James
Aug 3, 1999·British Journal of Obstetrics and Gynaecology·B A Stoll
Apr 27, 2012·Reproductive Sciences·Kewei ShangYoufei Guan
Dec 20, 2005·Human Reproduction·O C PillayP Hardiman
Sep 12, 2020·Cancers·Iwona SidorkiewiczAdam Krętowski
Aug 10, 2017·Journal of Ovarian Research·Ricardo Santos SimõesEdmund C Baracat
Apr 16, 2003·Journal of Cancer Research and Clinical Oncology·L M BersteinJ H H Thijssen
Jul 21, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Gokalp OnerFigen Ozturk

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