The effect of insulin resistance on prognosis of non-diabetic patients who underwent percutaneous coronary intervention.

Journal of Korean Medical Science
Kyeong Ho YunJung Chaee Kang

Abstract

Insulin resistance is an important risk factor for coronary artery disease. However, there has been no data regarding its clinical effect on the outcomes of percutaneous coronary intervention (PCI) in non-diabetic patients. We analyzed 98 non-diabetic consecutive patients (59+/-11.5 yr, male:female=63:35) who underwent elective coronary angiography. The patients were divided into two groups: Group I (n=71; the value of HOMA-IR [homeostasis model assessment of insulin resistance] <2.6) and Group II (n=27; the value of HOMA-IR > or = 2.6). In-hospital and 30-day major adverse cardiac events (MACE) were compared between the two groups. The concentrations of fasting insulin and triglyceride were significantly higher in Group II than in Group I. Significant correlations were observed between the value of HOMA-IR and body mass index (r=0.489, p<0.001), levels of total cholesterol (r=0.204, p=0.045), triglyceride (r=0.334, p=0.001) and apolipoprotein B (r=0.212, p=0.038). PCI was performed in 59 patients (60.2%). In-hospital and 30-day MACE were higher in Group II than Group I (2.4% vs. 27.8%, p=0.008; 2.4% vs. 27.8%, p=0.008). Multivariate analysis revealed that the value of HOMA-IR > or = 2.6 was an independent predictor of MACE. In...Continue Reading

References

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Oct 2, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Ki Chul SungSeung Ho Ryu

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Citations

Nov 6, 2008·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hyun-Young ParkKwang-Ho Cho
Jun 21, 2016·International Journal of Cardiology·Giuseppe CaminitiMaurizio Volterrani

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Methods Mentioned

BETA
dissection
coronary artery bypass

Software Mentioned

SPSS®

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