The effect of integrin-specific bioactive coatings on tissue healing and implant osseointegration.

Biomaterials
Timothy A PetrieAndrés J García

Abstract

Implant osseointegration, defined as bone apposition and functional fixation, is a requisite for clinical success in orthopaedic and dental applications, many of which are restricted by implant loosening. Modification of implants to present bioactive motifs such as the RGD cell-adhesive sequence from fibronectin (FN) represents a promising approach in regenerative medicine. However, these biomimetic strategies have yielded only marginal enhancements in tissue healing in vivo. In this study, clinical-grade titanium implants were grafted with a non-fouling oligo(ethylene glycol)-substituted polymer coating functionalized with controlled densities of ligands of varying specificity for target integrin receptors. Biomaterials presenting the alpha5beta1-integrin-specific FN fragment FNIII 7-10 enhanced osteoblastic differentiation in bone marrow stromal cells compared to unmodified titanium and RGD-presenting surfaces. Importantly, FNIII 7-10-functionalized titanium significantly improved functional implant osseointegration compared to RGD-functionalized and unmodified titanium in vivo. This study demonstrates that bioactive coatings that promote integrin binding specificity regulate marrow-derived progenitor osteoblastic differentia...Continue Reading

References

Oct 8, 1999·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·R F MeenanC G Helmick
Apr 18, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Steven K HanksJan Brábek
Oct 1, 2003·Journal of Biomedical Materials Research. Part a·Catherine D Reyes, Andrés J García
Apr 2, 2004·Nature·Robert Langer, David A Tirrell
Jul 2, 2004·Nature Biotechnology·Jeffrey A Hubbell
Nov 16, 2004·The Orthopedic Clinics of North America·Robert M Pilliar
Apr 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Benjamin G KeselowskyAndrés J García
Jul 8, 2005·Molecular Biology of the Cell·Nathan D GallantAndrés J García
Jul 9, 2005·Biomaterials·Andrés J García
Apr 24, 2007·Biomaterials·Catherine D ReyesAndrés J García
Apr 26, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Stefan RammeltHans Zwipp

❮ Previous
Next ❯

Citations

Apr 28, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K Anselme
Oct 20, 2011·Chemical Reviews·Steven R Meyers, Mark W Grinstaff
Jun 30, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Goher MahmudBartosz A Grzybowski
Aug 11, 2010·Tissue Engineering. Part a·Ashley C BrownThomas H Barker
Oct 2, 2012·Tissue Engineering. Part a·Daniel C Roy, Denise C Hocking
Jul 19, 2013·Tissue Engineering. Part a·Rick VisserManuel Cifuentes
Aug 20, 2010·Science Translational Medicine·Timothy A PetrieAndrés J García
Mar 2, 2010·Biological & Pharmaceutical Bulletin·Zhao-Hui JinYasuhisa Fujibayashi
Mar 29, 2014·ACS Applied Materials & Interfaces·Carlos Mas-MorunoF Javier Gil
Jul 24, 2012·Therapeutic Delivery·Kyung Jae Jeong, Daniel S Kohane
Jul 8, 2009·Regenerative Medicine·Ashley E Carson, Thomas H Barker
May 28, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Helena Felgueiras, Véronique Migonney
Jul 1, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tianxin MiaoRachael A Oldinski
Jul 8, 2014·International Journal of Molecular Sciences·Bill G X ZhangPeter F M Choong
Jan 7, 2016·ACS Applied Materials & Interfaces·Carolina Herranz-DiezJordi Guillem-Marti
May 8, 2013·Current Opinion in Biotechnology·Amy Y Cheng, Andrés J García
Feb 24, 2016·Scientific Reports·Jake J HayManuel Salmeron-Sanchez
Mar 5, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Rayk Hassert, Annette G Beck-Sickinger
Oct 31, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Birgit FinkeJ Barbara Nebe
Oct 30, 2015·Colloids and Surfaces. B, Biointerfaces·C Herranz-DiezC Selhuber-Unkel
Sep 23, 2008·Biomaterials·Amanda W BridgesAndrés J García
Apr 12, 2015·Advanced Drug Delivery Reviews·Rachit Agarwal, Andrés J García
Aug 12, 2009·Clinical Oral Implants Research·Rüdiger JunkerJohn A Jansen
Apr 17, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Qinyi LiuTheresa Freeman
Jan 4, 2012·Journal of Biomedical Materials Research. Part a·Nina BrogginiDaniel Buser
Jan 27, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Michael JonerRenu Virmani
Nov 26, 2010·Journal of Biomedical Materials Research. Part a·Asha Shekaran, Andrés J García
Mar 30, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·Nianli Zhang, David H Kohn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.