The effect of inter-laboratory variability on the protein:creatinine (UPC) ratio in canine urine

The Veterinary Journal
Gabriele RossiSaverio Paltrinieri

Abstract

Quantification of proteinuria is a fundamental step in staging dogs with chronic kidney disease and in monitoring the course of disease or the efficacy of anti-proteinuric treatments. Analytical precision and accuracy of the proteinuria assessment could be affected by several factors such as biological variability, different operators and quality control materials. The aim of this study was to assess whether inter-laboratory variability could affect the urinary protein to creatinine (UPC) ratio and whether this variability may affect patient classification according to the International Renal Interest Society (IRIS) sub-staging system. The same urine samples were analysed in three different laboratories using different instruments and different reagent brands. The results of the three laboratories were highly correlated to each other although urinary protein (UP), urinary creatinine (UC) and the UPC ratio of one laboratory were found to be significantly higher than those of the other two. No significant differences between the other two laboratories were recorded. The concordance in classifying dogs according to the IRIS guidelines was good if all three proteinuria categories were analysed separately or if borderline proteinuri...Continue Reading

References

Jun 8, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·T T KouriW G Guder
Jan 1, 1991·Veterinary Clinical Pathology·Frances M. MooreLynne Brown
Feb 11, 2005·Journal of the American Veterinary Medical Association·Frédéric JacobLaurie L Swanson
Jun 16, 2005·Journal of Veterinary Internal Medicine·George E LeesUNKNOWN American College of Veterinary Internal Medicine
Mar 7, 2012·Veterinary Clinical Pathology·Rebekah G Gunn-ChristieUNKNOWN American Society for Veterinary Clinical Pathology (ASVCP)
May 25, 2012·American Journal of Veterinary Research·Gabriele RossiSaverio Paltrinieri
Dec 18, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·John C LieskeUNKNOWN National Kidney Disease Education Program – IFCC Working Group on Standardization of Albumin in Urine (WG-SAU)
May 22, 2013·Journal of the American Animal Hospital Association·Marco PierantozziAndrea Zatelli

❮ Previous
Next ❯

Citations

Mar 5, 2016·Journal of Feline Medicine and Surgery·George Reppas, Susan F Foster
Jul 25, 2017·American Journal of Veterinary Research·Marie-Laure ThéronRachel Lavoué
Aug 23, 2018·Veterinary Clinical Pathology·Marco GiraldiPaola Scarpa
Feb 7, 2019·Journal of Feline Medicine and Surgery·Marco GiraldiPaola Scarpa
Feb 14, 2020·Journal of Veterinary Internal Medicine·Lindsey E CitronJonathan D Foster
Jun 6, 2020·Veterinary Clinical Pathology·Rebekah LiffmanThurid Johnstone
Aug 27, 2016·Veterinary Clinical Pathology·Gabriele RossiSaverio Paltrinieri
Nov 3, 2016·Veterinary Clinical Pathology·Saverio PaltrinieriEric Zini
Apr 25, 2019·Veterinary Medicine International·M GizzarelliA Zatelli
Nov 22, 2020·Animals : an Open Access Journal From MDPI·Marco GiraldiPaola Scarpa
Jul 9, 2021·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Labrini V AthanasiouZoe S Polizopoulou

❮ Previous
Next ❯

Related Concepts

Related Feeds