The effect of Interceed for reducing adhesion as a middle ear packing agent: an experimental study

International Journal of Pediatric Otorhinolaryngology
Chul Ho JangChel Hee Choi

Abstract

Interceed (oxidized regenerated cellulose) has been used to prevent postoperative abdominal adhesion. However, the efficacy and safety of using Interceed in middle ear surgery have not been thoroughly studied. The animals were divided into two groups: the Interceed group and the Gelfoam (Gelatin sponge) group. In every group, the study was performed on five guinea pigs (ten ears). Under the aseptic condition, the middle ear mucosa was abraded using a pick through a myringotomy incision. Interceed and Gelfoam were then packed into the guinea pigs' middle ear cavities. The auditory brainstem responses (ABRs) were assessed preoperatively and at 3 weeks after the operation with the animals under general anesthesia. Histopathologic study was performed 3 weeks after the operation. The ABR results on postoperative week 3 showed no statistically significant difference for myringotomy and postpacking. The fibrosis, middle ear mucosa thickening and adhesion formation appeared to be less in the Interceed group compared with the Gelfoam group. Any foreign body reaction was not observed in the Interceed group. Our results show that Interceed is nonototoxic and biocompatible with the guinea pig's middle ear cavity. Therefore, these results s...Continue Reading

References

Apr 21, 2004·Obstetrical & Gynecological Survey·Dania Al-Jaroudi, Togas Tulandi

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Citations

Feb 23, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Patrick J AntonelliDustin M Lang
Apr 27, 2011·The Laryngoscope·Yi ShenMarcus David Atlas
Oct 10, 2012·International Journal of Pediatric Otorhinolaryngology·Chul Ho JangSung In Kang
Apr 18, 2016·International Journal of Biological Macromolecules·Chul Ho JangGeun Hyung Kim
Dec 12, 2012·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·J Raúl Olmos-ZuñigaRogelio Jasso-Victoria Md
Aug 26, 2014·Brazilian Journal of Otorhinolaryngology·Débora Lopes BunzenSilvio da Silva Caldas Neto
Dec 8, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Se Heang OhJin Ho Lee

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