PMID: 2496710Jan 1, 1989Paper

The effect of interferon on cells persistently infected with HIV

AIDS
M Crespi

Abstract

In this study the effect of interferon (IFN) on uninfected cells (H9-) and cells infected (H9+) with HIV-1 was investigated. In both H9- and H9+, IFN was unable to inhibit Sindbis virus replication. HIV-1 replication was inhibited by a maximum of 22% at 1000 U/ml of IFN. In both H9- and H9+ cells IFN exhibited a limited antiproliferative effect. There was activation of the 2'-5' oligo-A-synthetase (E enzyme) and the protein kinase enzyme systems, but low activation of the ribonuclease F was seen in both H9- and H9+ cells. From these results it can be concluded that IFN produces a limited antiviral and antiproliferative effect in both H9- and H9+ cells, and a defective ribonuclease F pathway might be responsible for this limited activity.

Citations

Dec 29, 1998·Biochimie·F DianzaniM R Capobianchi
Jun 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C PerrinJ F Michiels
Feb 1, 1997·The American Journal of Dermatopathology·P AbajoE Daudén
Apr 5, 2008·PLoS Pathogens·Stephen D BarrFrederic D Bushman
Feb 1, 1990·Clinical Immunology and Immunopathology·R S KornbluthD D Richman
Nov 1, 1991·Cytokine·W L FarrarK A Clouse

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