The effect of interleukin-17 on the proliferation and invasion of JEG-3 human choriocarcinoma cells

American Journal of Reproductive Immunology : AJRI
Sutatip PongcharoenP Butkhamchot

Abstract

As there has been a study in mice showing the expression of IL-17 by decidual cells and the status of IL-17 receptor expression in human pregnancy is not known, we hypothesized that IL-17 may regulate human trophoblast proliferation and invasion. JEG-3 cell line was used as a model for human trophoblast. Immunohistochemitry and reverse transcriptase polymerase chain reaction techniques were used to identify IL-17 receptor protein and mRNA, respectively. The effects of IL-17 on JEG-3 cell proliferation and invasion were tested using the BrdU incorporation and the Matrigel invasion assays, respectively. IL-17 increased the invasive capacity of JEG-3 cells but had no effect on the proliferation and multinucleated formation of JEG-3 cells. In this JEG-3 cell model of human trophoblast, the IL-17R and IL-17 may have a regulatory role in trophoblast invasion.

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Citations

Dec 24, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Hai-Yan LiuJing-Pian Peng
Jul 17, 2014·Cellular & Molecular Immunology·Binqing FuHaiming Wei
Feb 14, 2007·American Journal of Reproductive Immunology : AJRI·Sutatip PongcharoenDonruedee Sanguansermsri
Mar 6, 2009·American Journal of Reproductive Immunology : AJRI·Sutatip Pongcharoen, Kwansuda Supalap
Feb 26, 2013·American Journal of Reproductive Immunology : AJRI·Fernando F MartinezClaudia C Motran
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Dec 18, 2009·American Journal of Reproductive Immunology : AJRI·Akitoshi NakashimaShigeru Saito
Mar 12, 2010·American Journal of Reproductive Immunology : AJRI·Akitoshi NakashimaShigeru Saito
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Jun 30, 2018·American Journal of Reproductive Immunology : AJRI·Oleg PavlovSergei Selkov
Jul 10, 2018·American Journal of Reproductive Immunology : AJRI·Kahinho P MuyayaloAi-Hua Liao
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Jul 19, 2020·International Immunopharmacology·Roghayeh JafarpourMorteza Motallebnezhad
May 1, 2021·International Journal of Molecular Sciences·Colm J McElwainCathal M McCarthy

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