The effect of interleukin 6 deficiency on myocardial signal transduction pathways activation induced by bacterial lipopolysaccharide in young and old mice.

Advances in Medical Sciences
Ewa TarasiukK Kaminski

Abstract

Exaggerated release of proinflammatory mediators during sepsis contributes to inadequate vasodilatation and depressed myocardial contractility, which lead to development of shock and circulatory collapse. The aim of the study was to evaluate the effect of IL-6 and aging on activation of intracellular signaling pathways in the myocardium induced by bacterial lipopolysaccharide (LPS) administration. LPS was injected intraperitoneally to male 3- and 24-month old mice with systemic IL-6 gene knock-out (IL-6KO) and the reference strain (WT). LPS was given intraperitoneally in single low (0.1 mg/kg) or high (10 mg/kg) dose, or in two doses (0.1 + 10 mg/kg) with 24-h delay. The expression and phosphorylation of STAT3, ERK1/2, Akt1/2/3 proteins in the left ventricular myocardium was evaluated after 24 h using Western blotting. Low LPS dose induced higher STAT3 phosphorylation only in old IL-6KO mice, not affecting ERK1/2 and Akt1/2/3 phosphorylation in any group. High LPS dose upregulated STAT3 phosphorylation similarly in all groups, reduced ERK1/2 expression in young WT mice and upregulated Akt1/2/3 expression and phosphorylation in young IL-6KO mice. Pretreatment with low LPS dose attenuated phosphorylation of STAT3 in both old grou...Continue Reading

References

Mar 1, 1996·Infection and Immunity·K TatedaK Yamaguchi
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·K TakedaS Akira
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·T K SenguptaL B Ivashkiv
Aug 6, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·R Ferrari
Jul 16, 2003·Trends in Immunology·Taro Fukao, Shigeo Koyasu
Oct 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jörg J JacobyXin-Yuan Fu
Jul 12, 2005·The Journal of Clinical Investigation·Tomohisa NagoshiAnthony Rosenzweig
Aug 19, 2007·Circulation·M W Merx, C Weber
Oct 6, 2007·Basic Research in Cardiology·Philipp Fischer, Denise Hilfiker-Kleiner
Jul 18, 2008·American Journal of Physiology. Renal Physiology·Zhu ZhouRobert W Schrier
Jun 9, 2009·Burns : Journal of the International Society for Burn Injuries·Lin WangWeike Tao
Jul 17, 2009·Pharmacological Reports : PR·Karol A KamińskiMaria M Winnicka
Jun 24, 2010·Heart Failure Reviews·Anthony FlynnPaul J Mather
Nov 9, 2012·International Journal of Biological Sciences·Stefan Rose-John
May 22, 2013·Folia Histochemica Et Cytobiologica·Tomasz Andrzej BondaMaria Malgorzata Winnicka
Jul 6, 2013·Critical Care : the Official Journal of the Critical Care Forum·Xavier RepesséAntoine Vieillard-Baron
Feb 4, 2012·World Journal of Critical Care Medicine·Prashant NasaOmender Singh
May 27, 2016·Cell Death & Disease·Y YangW Yi
Nov 28, 2017·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tomasz A BondaKarol A Kamiński
May 3, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Tomasz A BondaKarol A Kaminski
Jun 2, 2018·Circulation·Yuxiao SunQun S Zang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Tomasz A BondaKarol A Kamiński
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
J MysliwiecM M Winnicka
© 2021 Meta ULC. All rights reserved