The effect of intracarotid perfusion of cerebrospinal fluid from patients with subarachnoid hemorrhage on cerebrovascular reactivity in rats

Neurological Research
L C FavaroF J Gillingham

Abstract

Cerebrovascular resistance was measured in 10 rats with increasing dosages of 5-Hydroxytryptamine (5-HT). The internal carotid artery was perfused at constant flow with cerebrospinal fluid (CSF) from patients with ruptured intracranial aneurysms, and dose-response curves to 10 mu 1 boluses of 5-HT were compared with similar dose-response curves obtained during perfusion with Krebs' solution and with normal CSF (CSF-N). CSF from patients with subarachnoid hemorrhage (CSF-SAH) produced increased sensitivity to 5-HT.

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