PMID: 6179485Apr 1, 1982

The effect of intracerebroventricular infusion of morphine, methionine-enkephalin and D-Ala2-enkephalinamide on body temperature of rabbits

Archives internationales de physiologie et de biochimie
A M KoneckaA Misicka

Abstract

The effect of intracerebroventricular infusions of two synthetically obtained peptides: Met-enkephalin hydrochloride and D-Ala2-Met-enkephalinamide hydrochloride, and of morphine hydrochloride on rectal temperature was investigated in conscious rabbits. Morphine hydrochloride in a dose of 240 micrograms and D-Ala2-Met-enkephalinamide hydrochloride in doses of 240 and 3000 micrograms produced a hyperthermia which was accompanied by ear vasoconstriction and shivering. No such effect ensued after Met-enkephalin, possibly due to rapid enzymatic degradation of this compound. The concept of opioid involvement in the central thermoregulatory mechanism is discussed.

References

Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J W HoladayC H Li
Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J W HoladayC H Li
Apr 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·W G Clark
Sep 15, 1975·Life Sciences·A Goldstein, P J Lowery
Mar 1, 1976·European Journal of Pharmacology·B CoxP Lomax
Mar 1, 1972·British Journal of Pharmacology·M Sharkawi

Citations

Jan 1, 1983·Pharmacology & Therapeutics·W G Clark, J M Lipton
May 1, 1987·Peptides·A M KoneckaA W Lipkowski
Dec 1, 1985·Brain Research Bulletin·R A AhokasC M Blatteis

Related Concepts

Enkephalin-Met, Ala(2)-
Heat Loss
Endorphins
Enkephalin, Methionine
Enkephalins
Fever
Injections, Intraventricular
Morphine Sulfate (2: 1), Pentahydrate
Shivering
Vascular Constriction (Function)

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