The effect of intranasal fentanyl on the emergence characteristics after sevoflurane anesthesia in children undergoing surgery for bilateral myringotomy tube placement

Anesthesia and Analgesia
Julia C FinkelG Zalzal

Abstract

Children undergoing placement of bilateral myringotomy tubes (BMT) often exhibit pain-related behavior (agitation) in the postanesthesia care unit. We compared the emergence and recovery profiles of pediatric patients who received sevoflurane with or without supplementary intranasal fentanyl for BMT surgery. By using a prospective, double-blinded design, 150 children 6 mo to 5 yr of age, scheduled for routine BMT surgery, were anesthetized with sevoflurane (2%-3%) in a 60% N(2)O/O(2) gas mixture. Patients were randomized to receive equal volumes of intranasal saline (Control), 1 microg/kg fentanyl or 2 microg/kg fentanyl. A blinded observer evaluated each patient using a previously described 4-point agitation scale and the Steward recovery scale. Response to parental presence was observed after a score of six (full recovery) was achieved on the Steward recovery scale. There were no significant differences among the three groups regarding age, weight, surgeon, duration of anesthesia, or ear condition. Recovery times and emergence characteristic scores were not statistically different. Agitation scores were significantly reduced in the 2-microg/kg Fentanyl group as compared with the Control group (P = 0.012). Fentanyl 2 microg/kg...Continue Reading

References

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Citations

Apr 3, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·D Cohen-Salmon
Mar 16, 2013·Saudi Journal of Anaesthesia·Aparna Sinha, Jayashree Sood
Jul 15, 2005·Best Practice & Research. Clinical Anaesthesiology·Martin Jöhr, Thomas M Berger
Jan 5, 2011·Journal of Pain Research·Susan T Verghese, Raafat S Hannallah
Feb 5, 2014·Anesthesiology Clinics·Richard J Banchs, Jerrold Lerman
Dec 11, 2019·BMJ : British Medical Journal·Mary Ellen McCann, Sulpicio G Soriano
Nov 1, 2016·Paediatric Drugs·Arthura D Moore, Doralina L Anghelescu
May 23, 2003·Anesthesia and Analgesia·Terri Voepel-LewisAlan R Tait
Mar 16, 2007·Paediatric Anaesthesia·Christian BreschanRudolf Likar
Jan 13, 2015·Paediatric Anaesthesia·Marta SomainiPablo M Ingelmo
Dec 21, 2006·Anesthesia and Analgesia·Gordana P Vlajkovic, Radomir P Sindjelic
Nov 8, 2007·Paediatric Anaesthesia·Nicole AlmenraderPaolo Pietropaoli
May 26, 2010·Paediatric Anaesthesia·Samira A BajwaAllan M Cyna
Jul 6, 2011·Paediatric Anaesthesia·Stephanie MalarbiAndrew Davidson
Mar 28, 2020·Hospital Pharmacy·Sonia KaushalCorrie E Chumpitazi
Sep 13, 2014·The Cochrane Database of Systematic Reviews·David CostiPhilippa Middleton
Apr 6, 2013·Korean journal of anesthesiology·Deokkyu KimSeonghoon Ko
May 18, 2011·Paediatric Anaesthesia·Sophie R PestieauJulia C Finkel

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