PMID: 2484726Oct 23, 1989Paper

The effect of intrathecal galanin on the flexor reflex in rat: increased depression after sciatic nerve section

Neuroscience Letters
Z Wiesenfeld-HallinT Hökfelt

Abstract

The effect of intrathecal galanin (GAL) on the hamstring flexor reflex to sural nerve stimulation was compared in rats with intact and unilaterally sectioned sciatic nerves. GAL had a biphasic effect on the flexor reflex in rats with intact nerves, including facilitation, facilitation followed by depression and pure depression, in a dose-dependent manner. In axotomized rats, the depressive effect of GAL was significantly increased, occurring at lower drug concentrations. Furthermore, the degree of depression was significantly stronger with a more rapid onset after nerve section. It is concluded that along with an increase in GAL-like immunoreactivity in primary afferents, the inhibitory function of this neuropeptide is enhanced following axotomy. This functional change may be due to both pre- and postsynaptic mechanisms.

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Citations

Jan 1, 1995·Journal of Neural Transmission. General Section·B PrzewłockaR Przewłocki
Dec 24, 2004·Anatomy and Embryology·Wu QinyangKjell Hultenby
Oct 1, 1995·Neuroscience·J C FinleyD M Katz
Apr 1, 1995·The International Journal of Biochemistry & Cell Biology·K BedecsT Bartfai
Jun 7, 2005·Neuropeptides·Veena PuriNancy E J Berman
Nov 8, 2001·European Journal of Pharmacology·Z Wiesenfeld-Hallin, X J Xu
Oct 9, 2002·Trends in Pharmacological Sciences·Hong-Xiang Liu, Tomas Hökfelt
Nov 20, 2001·Current Opinion in Pharmacology·D WynickS B McMahon
Mar 3, 1999·The European Journal of Neuroscience·J X HaoZ Wiesenfeld-Hallin
May 3, 2000·The European Journal of Neuroscience·B HeppelmannM Pawlak
Apr 13, 2000·The European Journal of Neuroscience·B J KerrS W Thompson
Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Z Wiesenfeld-HallinT Bartfai
Dec 22, 1999·Anesthesiology·P M Dougherty, P S Staats
Nov 20, 2002·Neuroreport·Andrea BaconDavid Wynick
Mar 1, 1992·Acta Physiologica Scandinavica·K BedecsZ Wiesenfeld-Hallin
Feb 3, 1999·Annals of the New York Academy of Sciences·D WynickV Pachnis
Feb 3, 1999·Annals of the New York Academy of Sciences·Z Wiesenfeld-Hallin, X J Xu
Feb 3, 1999·Annals of the New York Academy of Sciences·M S RamerM A Bisby
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·Z Q XuT Hökfelt
May 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Fiona E HolmesDavid Wynick
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·H X LiuT Hökfelt
Apr 1, 1992·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·E Weihe
May 20, 2003·The European Journal of Neuroscience·Stefan GrassZsuzsanna Wiesenfeld-Hallin

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