The effect of intrauterine growth restriction upon fetal and postnatal hepatic glucose transporter and glucokinase proteins

Pediatric Research
H F SadiqSherin U Devaskar

Abstract

Employing immunohistochemical and Western blot analyses, we investigated the cellular localization (22-d fetal and 14-d postnatal animals) and concentrations (22-d fetal to 21-d postnatal animals) of rat hepatic glucose transporters (Glut 1 and Glut 2) and glucokinase in response to development and uteroplacental insufficiency with IUGR. Glut 1, the predominant fetal hematopoietic cellular isoform, persisted in postnatal hematopoietic islands and was noted minimally in fetal hepatic cellular membranes. A approximately 40% extrauterine decline in Glut 1 levels paralleled the decline in hematopoietic cells. IUGR increased the fetal hepatic Glut 1 levels in parallel with an expanded hematopoietic cell mass (p < 0.05). In contrast, IUGR failed to alter the 2-fold increase in extrauterine Glut 2 concentrations (1-7-d postnatal animals), the isoform found in fetal and postnatal hepatocytic cell membranes. Glucokinase, the nuclear enzyme, increased 25% postnatally. IUGR caused a 16% increase in fetal glucokinase levels and a approximately 25% decline at postnatal d 1 (p < 0.05) without a comparable change in the hepatocytic cell number (92 +/- 6 versus 86 +/- 4). We conclude that hepatic Glut 1 concentrations reflect the extramedullar...Continue Reading

References

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Citations

Feb 18, 2012·American Journal of Physiology. Endocrinology and Metabolism·Afshan AbbasiSherin U Devaskar
Aug 11, 2006·Journal of Paediatrics and Child Health·Patrick Kelly, Jean Koh
Nov 6, 2010·Endocrine Reviews·Floor Remmers, Henriette A Delemarre-van de Waal
Dec 31, 2004·American Journal of Physiology. Endocrinology and Metabolism·Manikkavasagar ThamotharanSherin U Devaskar
Feb 4, 2006·The Journal of Physiology·William W Hay
Mar 10, 1999·The American Journal of Physiology·U G DasS U Devaskar
Feb 19, 2016·Physiology·Sherin U Devaskar, Alison Chu
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M S AndersonS U Devaskar

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