PMID: 8990438Jan 1, 1997Paper

The effect of intrauterine transfusion on fetal bilirubin in red cell alloimmunization

Obstetrics and Gynecology
L A GoodrumKenneth J Moise

Abstract

To evaluate the change in fetal serum bilirubin levels in response to intrauterine transfusion for red cell alloimmunization. The records of 37 patients who underwent more than one intrauterine transfusion were reviewed. The following indices were extracted: pre- and post-transfusion fetal hematocrit, total and direct serum bilirubin, reticulocyte count, Kleihauer-Betke test results, volumes of intravascular and intraperitoneal transfusions, and the source used for transfusion. The data were compared for interval 1 (transfusion 1 to 2) and interval 2 (transfusion 2 to 3). The rates of change in bilirubin, reticulocyte count, and percent fetal cells on the Kleihauer-Betke test were defined as the differences between the initial values of one transfusion and the initial values of the next transfusion divided by the number of days between transfusions. Analysis of variance, sign-rank test, and linear regression analysis were used when appropriate. P < .05 was significant. The median number of intrauterine transfusions for each patient was 3 (range 2-8). Gestational ages ranged from 22 to 37 weeks. Total bilirubin remained above the 97.5 percentile for gestational age in all but five patients. There was a significant decrease in re...Continue Reading

References

May 1, 1992·American Journal of Obstetrics and Gynecology·C P Weiner
Aug 1, 1988·British Journal of Obstetrics and Gynaecology·I Z MacKenzieJ F Ferguson
Apr 1, 1988·American Journal of Obstetrics and Gynecology·P A GrannumJ C Hobbins

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Citations

Jan 2, 2008·American Journal of Obstetrics and Gynecology·Inge P De BoerFrans J Walther

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