The effect of intravenous administration of GABA and brain extracts on blood pressure in the rat

Clinical and Experimental Pharmacology & Physiology
J S HorvathD J Tiller


1. A rat bioassay was used to study pressor substances in brain extracts. 2. A compound with pressor activity in pentolinium-treated rats was extracted from brain, purified using Dowex, Sephadex electrophoresis and identified as gamma-aminobutyric acid (GABA) by HPLC and mass spectrometry. 3. Intravenous GABA (1-5 microgram) or brain extracts caused a dose dependent decrease in blood pressure in pentobarbitone-anaesthetized rats. 4. After ganglion blockade with pentolinium (2 mg/kg subcutaneously), GABA or brain extracts cause a dose dependent increase in rat blood pressure. 5. This pressor effect is reduced by alpha- and beta-blockers (intravenous phentolamine, 0.5 mg/kg and propranolol, 0.05 mg/kg). 6. It is concluded that GABA causes a fall in blood pressure by a central mechanism and ganglion blockade unmasks a pressor effect.


Jan 1, 1979·Biomedical Mass Spectrometry·P S CalleryL A Geelhaar
Dec 1, 1977·European Journal of Pharmacology·M J Antonaccio, D G Taylor
Jan 1, 1977·Progress in Brain Research·J S HorvathD J Tiller
Jan 1, 1976·Journal of Neurochemistry·S J Enna, S H Snyder
Dec 1, 1971·The American Journal of Physiology·D GantenJ Genest
Feb 1, 1971·The Journal of Experimental Medicine·C Fischer-FerraroS Finkielman
Oct 1, 1969·Journal of Neurochemistry·N H YessaianH C Buniatian
Dec 20, 1958·The Japanese Journal of Physiology·H TAKAHASHIF NOGUCHI

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