The Effect of Intravenous Dexamethasone on Sugammadex Reversal Time in Children Undergoing Adenotonsillectomy

Anesthesia and Analgesia
Ersel GulecHakki Unlugenc

Abstract

Dexamethasone has been shown to cause inhibition of sugammadex reversal in functionally innervated human muscle cells. In this prospective, double-blind, randomized, controlled study, we evaluated the effect of dexamethasone on the reversal time of sugammadex in children undergoing tonsillectomy and/or adenoidectomy. We recruited 60 patients with ASA physical status I to II, between the ages of 3 and 8 years, scheduled for elective tonsillectomy and/or adenoidectomy. After the induction of anesthesia, patients in group D received IV dexamethasone at a dose of 0.5 mg/kg within a total volume of 5 mL saline, whereas patients in group S received only 5 mL IV saline as the control group. At the end of surgery, all patients were given a single bolus dose (2 mg/kg) of sugammadex at reappearance of T2. Demographic data, hemodynamic variables, time to recovery (a train-of-four ratio of 0.9), time to tracheal extubation, and adverse effects were recorded. There was no statistical significance between 2 groups in time to recovery and time to extubation. Time to recovery was 97.7 ± 23.9 seconds in group D and 91.1 ± 39.5 seconds in group S (P = 0.436; 95% confidence interval, -10.3 to 23.5). Time to extubation was 127.9 ± 23.2 seconds and...Continue Reading

References

Apr 3, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Mokhtar ElhakimMona Refat
Jul 31, 2004·Paediatric Anaesthesia·Varol CelikerUlkü Aypar
Jan 7, 2005·Clinical Pharmacokinetics·David CzockUlla Häussler
Jun 28, 2005·International Journal of Pediatric Otorhinolaryngology·M Nil KaanAlper Daldal
Jul 19, 2008·Anesthesia and Analgesia·Glenn S MurphyJeffery S Vender
Mar 11, 2009·Journal of Critical Care·Anton BomKaren Thomson
May 22, 2010·Current Opinion in Anaesthesiology·Christopher RexFriedrich K Pühringer
Jun 13, 2013·Anesthesia and Analgesia·Yoshifumi KotakeJunzo Takeda
Oct 19, 2013·European Journal of Anaesthesiology·Stefan SoltészThomas Mencke

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Citations

Jun 20, 2017·JBI Database of Systematic Reviews and Implementation Reports·Cassie R Held, Mackenzie D Sullivan
Nov 20, 2016·Paediatric Anaesthesia·Joseph D Tobias
Nov 23, 2016·Journal of Clinical Anesthesia·Ozlem OzmeteAnıs Aribogan

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