The effect of intravenous erythromycin on esophageal motility in healthy subjects

American Journal of Surgery
G TzovarasJ S Vassilakis

Abstract

It has been confirmed that erythromycin has gastrokinetic properties of enhancing gastric emptying both in health and disease. The objective of the present study was to investigate any possible effect of erythromycin on esophageal motility. In 14 healthy subjects, standard esophageal manometry was performed before and after the intravenous administration of 200 mg of erythromycin. The calculated manometric parameters of esophageal motility were the lower esophageal sphincter (LES) pressure; the amplitude and duration of peristalsis at 5, 10, and 15 cm proximal to the LES; and the velocity and strength of peristalsis at 5 cm proximal to the LES. Erythromycin significantly increased the LES pressure (P<0.001), and the amplitude (P=0.002), duration (P=0.003), strength (P=0.014) and velocity (P=0.008) of peristalsis at 5 cm proximal to LES. Erythromycin also increased the amplitude of peristalsis at 10 cm proximal to the LES (P=0.035). Erythromycin affects the motility of the distal esophagus.

References

Feb 1, 1979·Gut·N D ChristofidesM A Ghatei
Dec 1, 1976·Gut·A J MeissnerE E Daniel
Jan 1, 1976·Journal of Applied Physiology·J B Hollis, D O Castell
Dec 1, 1991·Gastroenterology·S K SarnaM B Lee
Apr 12, 1990·The New England Journal of Medicine·J JanssensR Bouillon
Feb 1, 1986·Digestive Diseases and Sciences·T TomomasaZ Itoh
Jul 1, 1985·The Journal of Antimicrobial Chemotherapy·G P ZaraH D Ritchie

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Citations

Dec 10, 2009·Digestive Diseases and Sciences·Annapurna Korimilli, Henry P Parkman
Jan 1, 1997·Peptides·Z Itoh
May 1, 2001·Alimentary Pharmacology & Therapeutics·J I CurryM D Stringer
Aug 17, 2002·Alimentary Pharmacology & Therapeutics·E AthanasakisE Xynos
Jul 4, 1998·The British Journal of Surgery·G Tzovaras, B J Rowlands
Apr 19, 2000·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M Storr, H D Allescher
Feb 24, 2001·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M BortolottiM Miglioli
Apr 1, 2014·Digestive Diseases and Sciences·Donghua LiaoHans Gregersen
May 10, 2011·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Mandana Olivia Sigaroudinia, Anthony R Quayle
Aug 22, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L GrossiL Marzio
Nov 5, 2011·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M Di StefanoJ Tack
Oct 15, 2013·Annals of the New York Academy of Sciences·Anne Lund KrarupSami R Achem
Jul 25, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J BroadG J Sanger
May 12, 2009·Pharmacology & Therapeutics·Betty De SmetInge Depoortere
Jan 11, 2001·The American Journal of Gastroenterology·P KoutsoumbiE Xynos
Jan 25, 2019·Nature Reviews. Endocrinology·Eveline DelooseJan Tack

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