The effect of intravenous infusion of adenosine on electrically evoked hyperalgesia in a healthy volunteer model of central sensitization.

Anesthesia and Analgesia
B A ChizhWolfgang Koppert

Abstract

Human pain models invoking central sensitization, one of the key mechanisms of chronic pain, may be useful for characterizing new analgesics. A new model of electrical hyperalgesia can detect the efficacy of several analgesic mechanisms. Because IV adenosine can alleviate neuropathic pain, we investigated its effect on experimental sensitization. This was a double-blinded, randomized, two-period crossover study in 20 healthy volunteers. Current pulses (0.5 ms; 1 Hz) were applied intracutaneously to achieve pain rating of approximately 5 on a 0-10 numeric rating scale. Pain, areas of pinprick hyperalgesia, and tactile allodynia were assessed during the 2.5-h stimulation period. Adenosine (50 microg. kg(-1). min(-1)) and placebo were infused IV over 60 min. Additional testing was performed 24 h after each treatment. Adenosine reduced the area of pinprick hyperalgesia during the infusion compared with placebo; there was no significant effect on tactile allodynia or pain rating. The effect on hyperalgesia developed over 15 min and was significant (P < or = 0.05) for the rest of the infusion period. There was no difference between treatments at 24 h. Thus, in accordance with reports on neuropathic pain, adenosine reduced central sen...Continue Reading

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Citations

Mar 30, 2011·Molecular Pain·Ruth RuscheweyhJürgen Sandkühler
Jan 27, 2009·Brain Research Reviews·Boris A ChizhKlaus Schaffler
Oct 22, 2011·Expert Review of Neurotherapeutics·Lars Arendt-Nielsen, Hans Christian Hoeck
Jun 20, 2018·Scandinavian Journal of Pain·M DuschW Koppert
Mar 25, 2021·European Journal of Pain : EJP·Charles QuesadaLuis Garcia-Larrea

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