PMID: 2510116Sep 1, 1989Paper

The effect of intravenous lidocaine, tocainide, and mexiletine on spontaneously active fibers originating in rat sciatic neuromas

Pain
C ChabalK J Burchiel

Abstract

The effects of intravenously administered subanesthetic concentrations of lidocaine, tocainide, and mexiletine on spontaneously active fibers (SAFs) originating in 7-day-old rat sciatic neuromas were studied. Control injections of normal saline caused no decrease in SAF or discharge rate. Lidocaine and tocainide given in incremental doses of 5, 10, 15, 20 and up to 25 mg/kg caused nearly all observed SAFs to stop firing. Mexiletine given in doses of 3, 5, 7, 10 and up to 15 mg/kg showed similar results at lower doses. All agents decreased the sensitivity of SAF to mechanical stimulation. No conduction blockade occurred at these doses of intravenously administered local anesthetics. The demonstrated reduction in firing rate of SAF may explain the pain relief observed in clinical trials of these orally available agents.

References

Nov 1, 1977·Journal of Neurology, Neurosurgery, and Psychiatry·F BehseF Carlsen
Apr 1, 1978·Circulation·J L AndersonD C Harrison
Apr 1, 1978·The American Journal of Cardiology·E N MooreR A Moller
Mar 1, 1976·Archives of Neurology·M J BrownA K Asbury
Dec 1, 1985·Pain·Zsuzsanna Wiesenfeld-Hallin, Ulf Lindblom
Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·R J LipickyI M Stillman
Dec 1, 1980·American Heart Journal·T D Lawrie
Apr 1, 1981·Experimental Neurology·E M Korenman, M Devor
Dec 1, 1980·American Heart Journal·D E Jewitt
May 1, 1982·British Journal of Anaesthesia·R A BoasA Shahnarian
Nov 1, 1980·Journal of Neurosurgery·K J Burchiel
Mar 1, 1958·Anesthesia and Analgesia·J E STEINHAUS, D E HOWLAND
Feb 1, 1959·Journal of Neurology, Neurosurgery, and Psychiatry·E KUGELBERG, U LINDBLOM
May 1, 1963·Anesthesiology·J E STEINHAUS, L GASKIN
May 1, 1961·Anesthesia and Analgesia·E E BARTLETT, O HUTSERANI
Dec 29, 1951·Journal of the American Medical Association·A S KEATSH K BEECHER

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Citations

Jan 1, 1994·Annals of Neurology·M C Rowbotham
Feb 1, 1995·Annals of Neurology·M C RowbothamH L Fields
Mar 1, 1995·Der Schmerz·N I ChernyM Zenz
Nov 5, 2002·Current Pain and Headache Reports·David A O'Gorman, Srinivasa N Raja
Jan 21, 2004·Current Pain and Headache Reports·To-Nhu H Vu
Nov 27, 1992·Brain Research·O Matzner, M Devor
Sep 1, 1996·Journal of Pain and Symptom Management·B S GalerM C Rowbotham
May 10, 2005·Bioorganic & Medicinal Chemistry·Kalliopi DodouPaul W Groundwater
Feb 1, 1995·Archives of Physical Medicine and Rehabilitation·B S GoodmanD Denson
Dec 24, 1997·Brain Research·I Omana-ZapataK R Bley
Dec 31, 2002·European Journal of Pharmacology·Helle Kirstein ErichsenGordon Blackburn-Munro
Mar 26, 2003·European Journal of Pharmacology·Atsushi KohjitaniMasahiko Shimada
Aug 10, 2000·The Veterinary Clinics of North America. Small Animal Practice·L A LamontK A Mathews
Apr 16, 2003·Journal of Pain and Symptom Management·Ahmad Beydoun, Misha-Miroslav Backonja
Jul 1, 1999·Journal of Pain and Symptom Management·A P BaranowskiE Bonello
Feb 20, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Haim Shapiro
Jan 1, 2002·European Journal of Pain : EJP·Howard S Smith, Christine N Sang
Mar 4, 2000·European Journal of Pain : EJP·E KalsoR A Moore
Dec 14, 2004·Journal of Palliative Medicine·Jay ThomasCharles F von Gunten
Jun 27, 2007·Journal of Palliative Medicine·Gary McCleane
Aug 7, 2012·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Yong-Soon KwonKyong Shil Im
Mar 1, 2005·The Neurologist·R Norman Harden
Oct 6, 2010·Regional Anesthesia and Pain Medicine·Michael A FrölichTimothy J Ness
Jul 29, 2000·Australian and New Zealand Journal of Medicine·D W KissaneS Aranda
May 20, 2000·Acta Neurologica Scandinavica. Supplementum·N Attal, D Bouhassira
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Josephine LaiMichael S Gold
Apr 1, 1999·Annual Review of Physiology·E W McCleskey, M S Gold
Jul 11, 2006·Drugs & Aging·Lorenzo PrianoAlessandro Mauro
Apr 23, 2004·Drugs·Pamela S Davies, Bradley S Galer
Oct 2, 2009·Drugs·Karly P Garnock-Jones, Gillian M Keating
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·S G WaxmanJ A Black

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