The Effect of Intravenous Midazolam on Postoperative Nausea and Vomiting: A Meta-Analysis.

Anesthesia and Analgesia
Michael C GrantChristopher L Wu

Abstract

Research has shown that high-risk surgical patients benefit from a multimodal therapeutic approach to prevent postoperative nausea and vomiting (PONV). Our group sought to investigate the effect of administering IV midazolam on PONV. This meta-analysis included 12 randomized controlled trials (n = 841) of adults undergoing a variety of surgical procedures that investigated the effect of both preoperative and intraoperative IV midazolam on PONV in patients undergoing general anesthesia. Administration of IV midazolam was associated with significantly reduced PONV (risk ratio [RR] = 0.55; 95% confidence interval [CI], 0.43-0.70), nausea (RR = 0.62; 95% CI, 0.40-0.94), vomiting (RR = 0.61; 95% CI, 0.45-0.82), and rescue antiemetic administration (RR = 0.49; 95% CI, 0.37-0.65) within 24 hours. Individual subgroup analyses of trials excluding the use of thiopental for induction, trials of either female sex or high-risk surgery, trials involving nitrous oxide maintenance, and trials using midazolam in combination with known antiemetics all yielded similar reductions in PONV end points within 24 hours of surgery. Administration of preoperative or intraoperative IV midazolam is associated with a significant decrease in overall PONV, na...Continue Reading

Associated Clinical Trials

References

Jul 1, 1992·Anesthesiology·M F Watcha, P F White
Mar 2, 1999·Anaesthesia and Intensive Care·T Di Florio, C R Goucke
Apr 20, 2002·Anesthesiology·Christopher L WuLee A Fleisher
Oct 21, 2003·Journal of Anesthesia·N BaykaraK Toker
Jun 26, 2004·Journal of Clinical Anesthesia·Kevin P BauerJennifer E O'Flaherty
Jul 24, 2004·Anesthesia and Analgesia·Orathy Patangi Sanjay, Deepak Ivan Tauro
Jun 11, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Julie GolembiewskiTania Chopra
Oct 31, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jae Sik JungYoung Hoon Jeon
Nov 26, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jinseok YeoWoonyi Baek
Apr 16, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Yoshitaka Fujii, Michiyo Itakura
Dec 22, 2011·British Journal of Anaesthesia·A Chandrakantan, P S A Glass
Sep 6, 2014·Journal of Anaesthesiology, Clinical Pharmacology·Sherif A Abdelhamid, Mohamed Samir Kamel

❮ Previous
Next ❯

Citations

Oct 3, 2019·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Stefan van BeekRobert J Stolker
Oct 21, 2016·Anesthesia and Analgesia·Michael C GrantChristopher L Wu
May 7, 2016·Current Opinion in Anaesthesiology·John E Tetzlaff
May 30, 2020·Anesthesia and Analgesia·Tong J GanBeverly K Philip
Jun 6, 2017·Korean journal of anesthesiology·Taehee PyeonSeongwook Jeong
Jun 22, 2021·Current Opinion in Anaesthesiology·Basem B Abdelmalak, D John Doyle
Sep 25, 2021·Current Opinion in Anaesthesiology·Niraja Rajan, Girish P Joshi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.