PMID: 2112416Apr 9, 1990Paper

The effect of intraventricular administration of the 5-HT3 receptor agonist 2-methylserotonin on the release of dopamine in the nucleus accumbens: an in vivo chronocoulometric study

Brain Research
L H JiangR Y Wang

Abstract

In the present study we have examined the effects of the serotonin3 (5-HT3) agonist 2-methylserotonin (2-Me-5HT) on the dopamine (DA) release in the nucleus accumbens (NAc) of rats using in vivo chronocoulometric recording. The intraventricular (i.c.v.) administration of 2-Me-5HT dose-dependently increased the DA release in the NAc. This effect was blocked by the selective 5-HT3 antagonist BRL-43694 (granisetron), but not by the 5-HT1/5-HT2 antagonist metergoline. The i.c.v. injection of 8-hydroxydipropylaminotetraline (8-OHDPAT, a selective 5-HT1a agonist) or (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI, a 5-HT2/5-HT1c agonist) failed to alter the DA release in the NAc. The increase in the DA release produced by 2-Me-5HT was abolished in animals that had received acute bilateral injections of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle. Our results suggest that the 2-Me-5HT-induced DA release in the NAc is mediated by 5-HT3 receptors. In addition, 2-Me-5HT induced effect is dependent upon the impulse flow of DA cells.

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Citations

May 1, 1992·Neurochemical Research·K Yoshimoto, W J McBride
Jun 1, 1994·Psychopharmacology·S A TancoB B Gorzalka
Jan 1, 1993·Psychopharmacology·K A YoungP B Hicks
Apr 1, 1995·Journal of Biomedical Science·W.-H. WuC.-S. Tung
Jul 23, 1991·European Journal of Pharmacology·S Benloucif, M P Galloway
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May 1, 1991·Pharmacology, Biochemistry, and Behavior·R Peltier, S Schenk
Oct 1, 1991·Pharmacology, Biochemistry, and Behavior·R B RothmanA Pert
Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·R B RothmanA Pert
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·G R KingE H Ellinwood
Jul 1, 1996·Pharmacology, Biochemistry, and Behavior·R De La GarzaK A Cunningham
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·J M Witkin
Jan 1, 1994·Pharmacology & Therapeutics·D M Jackson, A Westlind-Danielsson
May 1, 1995·Drug and Alcohol Dependence·K A Grant

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