The effect of intravitreal injection of vehicle solutions on form deprivation myopia in tree shrews

Experimental Eye Research
Alexander H WardThomas T Norton

Abstract

lntravitreal injection of substances dissolved in a vehicle solution is a common tool used to assess retinal function. We examined the effect of injection procedures (three groups) and vehicle solutions (four groups) on the development of form deprivation myopia (FDM) in juvenile tree shrews, mammals closely related to primates, starting at 24 days of visual experience (about 45 days of age). In seven groups (n = 7 per group), the myopia produced by monocular form deprivation (FD) was measured daily for 12 days during an 11-day treatment period. The FD eye was randomly selected; the contralateral eye served as an untreated control. The refractive state of both eyes was measured daily, starting just before FD began (day 1); axial component dimensions were measured on day 1 and after eleven days of treatment (day 12). Procedure groups: the myopia (treated eye - control eye refraction) in the FD group was the reference. The sham group only underwent brief daily anesthesia and opening of the conjunctiva to expose the sclera. The puncture group, in addition, had a pipette inserted daily into the vitreous. In four vehicle groups, 5 μL of vehicle was injected daily. The NaCl group received 0.85% NaCl. In the NaCl + ascorbic acid group...Continue Reading

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Citations

Jun 2, 2015·PloS One·Yong WangXingwu Zhong
Sep 5, 2018·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Timothy J GawneThomas T Norton
May 8, 2020·Stem Cells Translational Medicine·Djida GhoubayVincent M Borderie
Apr 18, 2021·Experimental Eye Research·Qiong WangRuihua Wei
May 19, 2021·Translational Vision Science & Technology·Mustapha El HamdaouiRafael Grytz
Feb 11, 2020·Current Stem Cell Research & Therapy·Nanxin LiuGang Fu

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