PMID: 1212981Oct 1, 1975Paper

The effect of iodide administration on hog thyroid gland and the composition of thyroglobulin and 27-S iodoprotein

Endocrinologia Japonica
O TarutaniK Horiguchi-Sho

Abstract

The effect of excess iodide on hog thyroid gland has been examined with regard to the change in the chemical composition of thyroglobulin and in the accumulation of 27-S iodoprotein by the in vivo treatment of hogs with iodide for various lengths of time. The iodine content of thyroglobulin was either unchanged by short term administration of excess iodide, or somewhat lowered. However, the iodine content as well as the total amount of thyroglobulin increased in the glands enlarged by prolonged treatment with iodide. The iodine highest reached 1.17% of the protein on an average. On the other hand, 27-S iodoprotein decreased and finally disappeared after the chronic treatment. Monoiodotyrosine and diiodotyrosine increased in parallel with the increase in the iodine content (0.15 to 1.17%) caused by the iodide treatment, while thyroxine increased but reached a plateau at the level of three residues per mole of thyroglobulin, and no change was observed even in the proteins with the higher iodine content than 0.75%. Proteolytic activity measured by amino acid release from the thyroid protein was depressed by the chronic treatment. On the other hand, the amount of iodocompound released by the autoproteolysis, which may reflect hormo...Continue Reading

Citations

Dec 12, 1977·Pflügers Archiv : European journal of physiology·S Smeds
Jan 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·B AnderbergS Smeds
Nov 21, 1997·Biochimica Et Biophysica Acta·M IkekitaO Tarutani

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