PMID: 6403024Mar 1, 1983Paper

The effect of iron deficiency on experimental oral carcinogenesis in the rat

British Journal of Cancer
S S PrimeJ S Rennie

Abstract

The effect of iron deficiency on oral carcinogenesis was investigated in 30 young adult male Charles River white rats. In 15 animals, prior to the start of carcinogen treatment, iron deficiency anaemia was produced and subsequently maintained by a combination of low iron diet (12 mg Fe2+ kg-1 diet) and repeated venesection. Fifteen control animals were fed the same diet supplemented with iron to approximately 140 mg FE2+ kg-1 diet. All animals were treated with the carcinogen 0.5% 4-Nitroquinoline-N-oxide in propylene glycol which was painted on the palate 3 times weekly. Animals were killed when tumours were grossly evident. The mean haemoglobin levels at the start of carcinogen applications were 10.1 g dl-1 in the anaemic group and 14.1 g dl-1 in the control group, and at the time of killing were 8.2 g dl-1 in anaemic animals and 13.8 g dl-1 in controls. The incidence of animals developing squamous cell carcinomas was similar in both groups, but tumour development was significantly earlier in iron-deficient animals (mean 183 days) compared to controls (mean 229 days). Iron-deficient animals showed a significantly greater incidence of tongue tumours and control animals showed a significantly greater incidence of palatal tumours.

Citations

Dec 1, 1989·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A W RanasingheR A Williams
Jul 1, 1984·Journal of the Royal Society of Medicine·J S RennieJ H Dagg
May 27, 2015·Environmental and Molecular Mutagenesis·Chad M ThompsonDeborah M Proctor
Jan 1, 1990·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·S J Gerson
May 1, 1986·Journal of Oral Pathology·S S PrimeJ Rennie
Jun 28, 2008·Nutrition and Cancer·John P RichieJoshua E Muscat
Sep 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Negar MafiAli Zare-Mirzaie
Jul 18, 2020·Nutrition Reviews·Oliver PhippsHafid O Al-Hassi
Oct 20, 2009·Nutrition and Cancer·Daniel PráMichael Fenech
Jan 1, 1986·Differentiation; Research in Biological Diversity·S S PrimeC Scully

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