The effect of iron dosing schedules on plasma hepcidin and iron absorption in Kenyan infants

The American Journal of Clinical Nutrition
Mary A UyogaMichael B Zimmermann

Abstract

In adults, oral iron doses increase plasma hepcidin (PHep) for 24 h, but not for 48 h, and there is a circadian increase in PHep over the day. Because high PHep decreases fractional iron absorption (FIA), alternate day iron dosing in the morning may be preferable to consecutive day dosing. Whether these effects occur in infants is uncertain. Using stable iron isotopes in Kenyan infants, we compared FIA from morning and afternoon doses and from consecutive, alternate (every second day) and every third day iron doses. In prospective studies, we measured and compared FIA and the PHep response from 1) meals fortified with a 12-mg iron micronutrient powder given in the morning or afternoon (n = 22); 2) the same given on consecutive or alternate days (n = 21); and 3) a 12-mg iron supplement given on alternate days or every third day (n = 24). In total, 65.7% of infants were anemic. In study 1, PHep did not differ between morning and afternoon (P = 0.072), and geometric mean FIA[-SD, +SD](%) did not differ between the morning and afternoon doses [15.9 (8.9, 28.6) and 16.1 (8.7, 29.8), P = 0.877]. In study 2, PHep was increased 24 h after oral iron (P = 0.014), and mean FIA [±SD](%) from the baseline dose [23.3 (10.9)] was greater than...Continue Reading

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Citations

Aug 28, 2020·The American Journal of Clinical Nutrition·Jacquelyn M Powers, Michael Auerbach
Mar 4, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Staffan K Berglund, Magnus Domellöf
May 29, 2021·Archives of Disease in Childhood. Education and Practice Edition·Joseph MachtaSarah Eisen
Aug 28, 2021·The Lancet. Haematology·Hal DrakesmithMichael B Zimmermann

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