The effect of iron overload in the hearts of patients with beta-thalassemia

Clinical Cardiology
Stella BriliP K Toutouzas

Abstract

An important complication of beta-thalassemia is iron deposition in cardiac tissues resulting in fibrosis and dysfunction. Our aim was the investigation of the possible clinical effect of iron loading in the heart of patients with beta-thalassemia prior to the appearance of symptoms of depressed systolic function. Thirty-five patients with beta-thalassemia, of whom 24 had the major type (Group 1) and 11 had the intermedia type (Group 2) were studied. Eleven age- and gender-matched controls were also studied (Group 3). All patients were evaluated echocardiographically and were shown to have normal left ventricular systolic function and dimensions. Serum ferritin, atrial natriuretic peptide (ANP), left atrial diameter (LAD), peak early mitral inflow velocity (E), peak late mitral inflow velocity (A), E/A ratio, deceleration time of the mitral inflow E wave (DT), and isovolumic relaxation time (IVRT) were measured. Univariate analysis showed that both groups of patients had similarly increased LAD and ANP plasma levels. Group 1 had a higher E/A ratio (2.27 +/- 0.88) SS than Group 2 (1.69 +/- 0.47, p = 0.05) and Group 3 (1.50 +/- 0.38, p = 0.01). Serum ferritin was significantly higher in Group 1 (3.526 +/- 0.352) than in Group 2 (...Continue Reading

References

Jul 1, 1989·Archives of Disease in Childhood·K C LauC Y Yeung
Jul 1, 1986·Journal of the American College of Cardiology·R J RodehefferT Inagami
Aug 22, 1986·JAMA : the Journal of the American Medical Association·D M AckermannJ C Burnette
Aug 28, 1986·The New England Journal of Medicine·A E RaineF R Bühler
Dec 1, 1986·The Journal of Clinical Endocrinology and Metabolism·T YamajiT Nakayama
Feb 1, 1987·The Journal of Clinical Endocrinology and Metabolism·R S ZimmermanJ C Burnett
Mar 1, 1987·American Heart Journal·K ObataH Matsuo
May 1, 1987·European Heart Journal·T HednerA Pettersson
Oct 1, 1988·The American Journal of Cardiology·R D RossR A Meyer
Jan 1, 1985·Endocrine Reviews·M Cantin, J Genest
Jan 1, 1974·Annals of the New York Academy of Sciences·S PiomelliW J Kuhns
Aug 1, 1971·The American Journal of Medicine·L M Buja, W C Roberts
Sep 1, 1993·Circulation·D T KremastinosP K Toutouzas
Oct 7, 1964·Annals of the New York Academy of Sciences·M A ENGLE
Sep 1, 1987·Trends in Ecology & Evolution·K B Armitage

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Citations

Feb 6, 2004·BioFactors·D R LaksmitawatiH J Freisleben
Nov 6, 1998·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·W A SuarezC R Patel
Dec 25, 2008·The International Journal of Cardiovascular Imaging·Tayfun UçarMehmet Ertem
Jun 19, 2007·La Presse médicale·Sandra JanowerAriel Cohen
Feb 24, 2007·European Journal of Heart Failure·Dimitrios Th KremastinosEvangelia D Kapsali
Feb 16, 2007·European Journal of Heart Failure·Athanasios AessoposEvanthia Diamanti-Kandarakis
Aug 18, 2010·Annals of the New York Academy of Sciences·John Malcolm Walker, Sunil Nair
May 15, 2018·Expert Review of Hematology·Natthaphat Siri-AngkulNipon Chattipakorn
Apr 6, 2019·Journal of Magnetic Resonance Imaging : JMRI·Christian A BarreraHansel J Otero
May 11, 2020·Hellenic Journal of Cardiology : HJC = Hellēnikē Kardiologikē Epitheōrēsē·Maria VlachouHaralambos Karvounis

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