PMID: 15384024Sep 24, 2004Paper

The effect of iron stores on corrected QT dispersion in patients undergoing peritoneal dialysis

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Vin-Cent WuKwan-Dun Wu

Abstract

Arrhythmia and sudden death represent striking features in patients with end-stage renal disease (ESRD). Increased QT dispersion has been shown to be associated with arrhythmias. Abnormal excitability and heterogeneous cardiac iron deposition may cause the arrhythmogenesis of human siderotic heart disease. Iron overload and precipitation with its toxicity in cardiac muscles may, therefore, cause QT prolongation in dialysis patients. A total of 102 (65 women, 37 men; mean age, 47.7 +/- 13.4 years) nondiabetic patients undergoing peritoneal dialysis (PD) were enrolled in this study. Another 102 subjects with a serum creatinine level less than 1.5 mg/dL (133 micromol/L) were used as matched control subjects. The PD patients were divided into 2 groups according to whether their computerized measurements of corrected QT (QTc) dispersion were longer than 74 ms. A value of 74 ms has been associated with risk for serious arrhythmias related to sudden death in dialysis patients. The QTc dispersion of PD patients was significantly longer than that of the control subjects (69.8 +/- 40.0 versus 55.2 +/- 33.6 ms; P < 0.01). Thirty-eight PD patients with QTc dispersion longer than 74 ms had lower blood pressure ( P = 0.01), fewer left ventri...Continue Reading

Citations

Nov 9, 2010·Journal of Cardiac Failure·Colm J Murphy, Gavin Y Oudit
Jul 22, 2008·Hemodialysis International·Manish M SoodCharmaine E Lok
Mar 20, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·L R ZacharskiC J Cornell
Apr 16, 2013·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·L Mascitelli, M R Goldstein
Sep 18, 2010·Journal of the American College of Cardiology·Pradeep GujjaYukitaka Shizukuda
May 14, 2016·International Journal of Cardiology·L Di LulloC Ronco
Dec 5, 2012·BMC Nephrology·Beata Franczyk-SkóraJacek Rysz
Apr 11, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Gavin Y OuditPeter H Backx
Feb 2, 2011·Nature Reviews. Nephrology·M Khaled Shamseddin, Patrick S Parfrey
May 10, 2005·Nephrology·Vin-Cent WuKwan-Dun Wu

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