PMID: 6402051Feb 1, 1983Paper

The effect of isotonic amino acid infusions on serum proteins and muscle breakdown following surgery

The British Journal of Surgery
O J GardenD C Carter

Abstract

Twenty patients undergoing major surgical procedures received constant infusion (21/day) of either 3.5 per cent amino acid (AA) or 5 per cent dextrose (D5W) solutions in addition to other fluid requirements for 4 postoperative days. Ketosis was evident in AA patients as a mean daily beta-hydroxy butyrate excretion of 2.16 +/- 1.39 mmol and respiratory quotient of 0.708 +/- 0.013 compared with 0.28 +/- 0.45 mmol/day and 0.754 +/- 0.015 respectively in the D5W group. The serum total protein and albumin concentrations (but not those of transferrin and prealbumin) were significantly higher in the AA than the D5W group on day 4. However, the mean fluid balance for days 3 and 4 was significantly less positive in AA patients. The mean daily nitrogen balance of -6.6 +/- 7.7 gN/day in AA patients and -9.5 +/- 5.8 gN/day in D5W patients was not significantly different. Mean daily 3-methyl histidine excretion (38.2 +/- 12.3 mumol/mmol creatinine) in AA patients was significantly higher than in D5W patients (31.2 +/- 10.8 mumol/mmol creatinine). With no improvement in nitrogen balance, an increase in muscle protein breakdown and the possibility that decreased fluid retention explains the higher serum total protein and albumin levels, this ...Continue Reading

References

Jan 1, 1977·JPEN. Journal of Parenteral and Enteral Nutrition·M V KaminskiD E Carlson
Jul 24, 1975·The New England Journal of Medicine·H C HooverA S Ketcham
Jun 24, 1976·The New England Journal of Medicine·G R GreenbergK N Jeejeebhoy
Nov 4, 1976·The New England Journal of Medicine·J J SkillmanM S Fang
Aug 1, 1975·Metabolism: Clinical and Experimental·C L LongJ W Geiger
Sep 1, 1974·The Journal of Clinical Endocrinology and Metabolism·R C O'ConnellF D Moore
Apr 1, 1973·American Journal of Surgery·G L BlackburnT E O'Donnell
Feb 1, 1973·Metabolism: Clinical and Experimental·D E TweedleI D Johnston
May 1, 1980·The Proceedings of the Nutrition Society·A Fleck
Jul 15, 1980·The Biochemical Journal·D J MillwardM J Rennie

❮ Previous
Next ❯

Citations

Jun 1, 1984·Digestive Diseases and Sciences·R L Koretz
Oct 1, 1988·Baillière's Clinical Gastroenterology·M J McMahon
Jul 29, 2005·The Proceedings of the Nutrition Society·Ronald L Koretz
Oct 7, 2003·Annual Review of Nutrition·Lyn Howard, Christopher Ashley
Aug 1, 1991·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J BroomW G Simpson
Dec 1, 1989·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·D T HansellH J Burns
Mar 1, 1984·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·S L BlameyD C Carter
Mar 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·P NeuvonenT Havia
Sep 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·B M HogbinA H Craven
Jul 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·D T HansellD C Carter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
A M Woolfson, J A Smith
Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
F J Jiménez JiménezJ G Montero
© 2021 Meta ULC. All rights reserved