The effect of jejunal meal feeding on gastroesophageal reflux

Scandinavian Journal of Gastroenterology
H C LienG H Chen

Abstract

Postprandial gastric distention is frequently associated with transient lower esophageal sphincter relaxation and gastroesophageal reflux (GER). Since the role of nutrient perfusion into the jejunum in inducing GER is not well understood, we studied the effect of jejunal feeding on GER through a percutaneous gastrojejunal tube in patients with and without reflux esophagitis. Nine stroke patients with reflux esophagitis were fed through a percutaneous gastrojejunal tube with either a liquid meal (2 kcal/2 ml/min) or saline for 2 h randomly on 2 separate days. An esophageal pH probe was placed 5 cm above the gastroesophageal junction to detect acid reflux. Six stroke patients without esophagitis were enrolled as controls. In both the patients with esophagitis and the controls, esophageal acid exposure (15.3% (4.9%-28.2%) versus 2.7% (0.0%-10.8%), P=0.003; 5.9% (0.5%-6.7%) versus 0.0% (0.0%-1.5%), P = 0.01) and events of acid reflux (5 (1-16) versus 2 (0-8), P = 0.02; 12 (3-17) versus 1 (0-4), P = 0.02) were significantly greater during jejunal meal feeding than during saline infusion. Furthermore, in the reflux patients, but not in the controls, acid clearance time was also greater during jejunal meal feeding than during saline i...Continue Reading

Citations

May 1, 2015·Expert Review of Gastroenterology & Hepatology·Teresa CapriatiAntonella Diamanti
Apr 6, 2011·Journal of Pediatric Gastroenterology and Nutrition·Rachel RosenMary Warlaumont
Jul 18, 2014·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·David B A Silk
Apr 30, 2011·JPEN. Journal of Parenteral and Enteral Nutrition·Norma A MethenyStephen A McClave
Oct 19, 2012·The Cochrane Database of Systematic Reviews·Chamila GeeganagePhilip M W Bath

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