The effect of KETODEX on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane based-anesthesia

International Journal of Pediatric Otorhinolaryngology
Sally M HadiWen Ouyang

Abstract

Postoperative emergency agitation (EA) is a common problem often observed in children undergoing general anesthesia. The purpose of this study was to evaluate whether a bolus of intraoperative low-dose ketamine followed by dexmedetomidine i.v. could reduce the incidence of EA in children undergoing adenotonsillectomy following sevoflurane-based anesthesia. A total of 92 children undergoing adenotonsillectomy, aged 3-7 years, were randomly allocated to receive either low-doseketamine 0.15 mg/kg followed by dexmedetomidine 0.3 μg/kg i.v. (KETODEX, n=45) or volume-matched normal saline (Control, n=47), about 10 min before the end of surgery. Anesthesia was induced and maintained with sevoflurane. Postoperative pain and EA were assessed with objective pain score (OPS) and the Pediatric Anesthesia Emergence Delirium scale (PAED), respectively. EA was defined as a PAED≥10 points. Recovery profile and postoperative complications were recorded. The incidence and severity of EA was lower in KETODEX group than controls (11% vs. 47%) and (2% vs. 13%), respectively (P<0.05). The frequency of fentanyl rescue was lower in KETODEX group than in controls (13.3 vs. 38.3%, P<0.05). Heart rate during extubation was significantly higher in the con...Continue Reading

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Citations

Apr 21, 2017·The Journal of International Medical Research·Ji-Feng FengJian-Lan Mo
May 26, 2017·Current Opinion in Anaesthesiology·Cedric E Sottas, Brian J Anderson
Jun 3, 2020·The Annals of Otology, Rhinology, and Laryngology·Dhivyaa AnandanAmy S Whigham
Feb 22, 2018·Aesthetic Plastic Surgery·Canser Yilmaz Demir, Nureddin Yuzkat
Nov 1, 2016·Paediatric Drugs·Arthura D Moore, Doralina L Anghelescu
Mar 27, 2020·Korean journal of anesthesiology·Seok-Jin Lee, Tae-Yun Sung
Nov 27, 2020·Journal of Pain Research·Faris AlghamdiArlyne K Thung
Jan 30, 2021·Anesthesiology Research and Practice·Tiffany H WongApolonia E Abramowicz

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