The effect of KIR and HLA polymorphisms on dengue infection and disease severity in northeastern Thais

Medical Microbiology and Immunology
Suwit ChaisriChanvit Leelayuwat

Abstract

Killer cell immunoglobulin-like receptors (KIRs) are cell surface receptors on natural killer (NK) cells and subsets of T cells. The interaction between KIRs and their cognate ligands (Human leukocyte antigen class I molecules, HLA class I) modulates the immune response of NK cells, in particular through clearance of virus-infected cells. Here, we investigated the effect of KIRs and HLA ligands on dengue infections and disease severity. The KIRs and HLA ligands were identified in 235 healthy controls (HC) and 253 dengue patients (DEN) using polymerase chain reaction with sequence specific primer (PCR-SSP); moreover, DEN was classified to 100 dengue fever (DF) and 153 dengue haemorrhagic fever (DHF). Risks were expressed as odds ratios (ORs) and 95% confidence intervals (CIs) with significance set at a two-tailed P value of < 0.05. The Bonferroni correction was applied for multiple comparisons. Twelve significant associations were observed in dengue infections and disease severity; however, two outcomes survived after the Bonferroni correction. Of these, HLA-A11 was associated with an increased risk to develop dengue disease (OR 2.41, 95% CI 1.62-3.60, Pc = 0.004), while KIR3DS1+Bw4 was a protective genotype to developing DHF (O...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Jan 1, 1996·Immunogenetics·C DöhringM Colonna
Jan 16, 1998·Immunity·M UhrbergP Parham
Sep 20, 2001·The American Journal of Tropical Medicine and Hygiene·S B HalsteadD M Watts
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heather G ShillingPeter Parham
Jul 23, 2002·Nature Genetics·Maureen P MartinMary Carrington
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maureen P MartinMary Carrington
Jun 12, 2003·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Edward C Holmes, S Susanna Twiddy
May 18, 2004·Arthritis and Rheumatism·T MomotT Witte
Sep 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·George W NelsonMary Carrington
Mar 18, 2005·Annual Review of Immunology·Lewis L Lanier
Apr 20, 2005·Nature Genetics·Anavaj SakuntabhaiCécile Julier
Aug 27, 2005·Molecular Interventions·Anthony P WilliamsSalim I Khakoo
Jul 11, 2006·Annual Review of Genomics and Human Genetics·Arman A BashirovaMary Carrington
Jan 5, 2007·Viral Immunology·Beatriz de la C SierraMaría G Guzmán
Nov 21, 2007·The Journal of Experimental Medicine·Galit AlterMarcus Altfeld
Feb 14, 2008·European Journal of Human Genetics : EJHG·Ronald E BlantonM Glória Teixeira
May 23, 2008·Nature·Szu-Ting ChenShie-Liang Hsieh
Jul 19, 2008·Seminars in Immunology·Smita KulkarniMary Carrington
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maelig MorvanChristelle Retière
Mar 17, 2010·Tissue Antigens·A V RomphrukC Leelayuwat
Jan 23, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·K AlagarasuD Cecilia
Feb 6, 2013·Human Immunology·K AlagarasuD Cecilia
Aug 12, 2016·Frontiers in Immunology·Jelle de WitDebbie van Baarle
Apr 23, 2017·Human Immunology·Suwit ChaisriAmornrat Romphruk
Apr 26, 2018·Frontiers in Immunology·Sudheer GuptaDebasis Biswas

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

Excel
SPSS19

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

© 2022 Meta ULC. All rights reserved