The effect of L-Dopa administration on pursuit ocular movements in suspected Parkinson's disease.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Silvia MarinoPlacido Bramanti

Abstract

The objective of this study is to evaluate pursuit ocular movements (POM) by using a vision-based non-intrusive eye tracker, in patients with suspected Parkinson's disease (PD), before and after L: -Dopa administration. We studied ten patients with suspected diagnosis of idiopathic PD. We compared POM values to those of a group of normal controls (NC), and evaluated them before and after L: -Dopa administration. Unified Parkinson's Disease Rating Scale (UPDRS) motor subscores improved significantly (p = 0.001). At baseline, values of POM were lower in suspected PD patients than in NC (p = 0.01). One hour after L: -Dopa administration, POM values correlated with UPDRS motor subscore (p = 0.01). We used a recent method, a new vision-based non-intrusive eye tracker, previously described, which can be proposed as a possible tool for supporting the diagnosis of PD in association with levodopa test, as an add-on to the UPDRS score.

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Citations

Aug 24, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Lorenzo De SantiSilvia Marino
Mar 13, 2017·Parkinsonism & Related Disorders·Merel S EkkerBastiaan R Bloem
Jul 11, 2018·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Maria G MaggioAlessia Bramanti
Dec 22, 2019·Medicine·Silvia MarinoGiuseppe Di Lorenzo
Jul 29, 2021·Clinical Parkinsonism & Related Disorders·Karen Frei

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