The effect of l-DOPA and benserazide on the amount of dopamine in the corpus striatum of X-irradiated rats

Experientia
S R Stepanović, J V Nikolić

Abstract

The effect of a mixture of l-DOPA and benserazide on the amount of dopamine in the corpus striatum of rats irradiated with 850 R of X-rays was investigated. The amount of dopamine in the corpus striatum was measured fluorimetrically at various times after irradiation. It was found that i.p. administration of l-DOPA and benserazide 1,2 and 5 days after irradiation produces significant replenishment of dopamine in the striatum, thus indicating that precursor uptake and metabolism, and probably amine storage, remained unaltered after irradiation.

References

Jun 15, 1977·Biochemical Pharmacology·C J Gibson, R J Wurtman
Jan 15, 1979·Experientia·S R Stepanović, J V Nikolić
Jul 12, 1974·Science·R J WurtmanJ D Fernstrom
May 1, 1969·The Journal of Pharmacy and Pharmacology·G Bartholini, A Pletscher
Jun 1, 1973·Acta Radiologica: Therapy, Physics, Biology·A DahlströmB Rosengren
Dec 15, 1958·Acta Physiologica Scandinavica·A CARLSSON, B WALDECK
Jun 1, 1951·British Journal of Pharmacology and Chemotherapy·C T ANDERSONR H MOLE

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.