The effect of L-dopa on the healing of a rat mandibular defect

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
G T JonesD M Laskin

Abstract

This study was designed to evaluate the effect of L-dopa on healing of a surgically created bony defect in the adult male rat. Thirty-six animals underwent surgery to create a 4-mm circular defect in the left mandibular angle. They were then randomly divided into two equal groups, one receiving 0.2 g/kg/day of L-dopa for 10 days by orogastric gavage, the other group acting as a control. Six experimental and six control animals were killed at 2 weeks, and five experimental and six control animals were killed at 4 and 6 weeks postoperation. Healing was classified as complete, partial, or incomplete based on gross and radiographic observations. Gross observation of the experimental mandibles showed five completely healed defects (31.25%), five partially healed defects (31.25%), and six defects with no healing (37.5%). Control mandibles showed three defects with partial healing (16.67%) and 15 with no healing (83.33%). Radiographs were taken of randomly chosen mandibles in each control and experimental group. Of the six experimental mandibles, one showed no healing, three showed partial healing, and two showed complete healing of the defect. The six control mandibles showed three defects with no bone formation and three with partia...Continue Reading

References

Dec 24, 1970·The New England Journal of Medicine·A E BoydJ B Pfeiffer

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Citations

Feb 6, 2004·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Jurjen SchortinghuisBoudewijn Stegenga
May 23, 2002·Journal of Endodontics·Mandana PartoviS Nasser Ostad
Jan 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bong-Hyuk ChoiSang Ho Jun
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Fahimeh TabatabaeiLobat Tayebi

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