The effect of labor and/or ovariectomy on rodent continence mechanism--the neuronal changes

World Journal of Urology
Karl-Dietrich SievertTom F Lue

Abstract

Many women develop stress urinary incontinence (SUI) after childbirth, but the exact neuronal changes are largely unknown. This study is designed to identify the neuronal changes associated with pregnancy, delivery and ovariectomy. A total of 10 virgin and 48 pregnant rats were used. Cystometry and stress/sneeze tests were performed in the virgin once and the pregnant rats at certain time points. Postpartum the rats were equally grouped as follows: group I: delivery, group II: delivery + ballooning, group III: delivery + ovariectomy, group IV: delivery + ballooning + ovariectomy. Tissues from bladder, bladder neck, and urethra were analyzed by immunostaining for PGP 9.5, CGRP, SP, NPY, VIP, TH, n-NOS. We found complex innervation changes in the different tissue samples. Since the bladder neck and the mid-urethra play an important role in the continence mechanism the neuronal changes in these areas contribute to the observed functional changes.

References

Jul 17, 1992·Science·A L BurnettS H Snyder
Oct 1, 1992·British Journal of Urology·C R ChappleG Burnstock
Dec 1, 1983·British Journal of Urology·J GuA R Mundy
Jan 1, 1994·World Journal of Urology·C H Hoyle
Jan 1, 1994·World Journal of Urology·K E Andersson, K Persson
Apr 8, 1995·Journal of the Autonomic Nervous System·K PerssonK E Andersson
Dec 19, 1998·Journal of the Autonomic Nervous System·V WerkströmK E Andersson
Aug 3, 2000·Journal of Perinatal Medicine·C Dannecker, C Anthuber
Mar 7, 2003·The New England Journal of Medicine·Guri RortveitUNKNOWN Norwegian EPINCONT Study

❮ Previous
Next ❯

Citations

Feb 14, 2006·World Journal of Urology·Karl-Dietrich SievertEmil A Tanagho
Jan 6, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H Q PanM S Damaser
Apr 22, 2008·The Journal of Urology·Adonis HijazMargot S Damaser
Sep 13, 2007·Neurourology and Urodynamics·Yi-Hao LinFirouz Daneshgari
Nov 15, 2008·BJU International·Elisabeth PauwelsJean-Jacques Wyndaele
Apr 19, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ronald J KimMargot S Damaser
Mar 25, 2014·Autonomic Neuroscience : Basic & Clinical·Z Al-NoahF Aura Kullmann
Mar 9, 2012·International Braz J Urol : Official Journal of the Brazilian Society of Urology·M SkaffFernando G Almeida
Dec 28, 2006·American Journal of Physiology. Renal Physiology·Rachelle L PrantilDavid A Vorp
Feb 24, 2012·Pharmacological Reports : PR·Marta Andres-MachJarogniew J Łuszczki
Aug 7, 2018·World Journal of Stem Cells·Jacobo TrébolDamián García-Olmo
Jul 21, 2020·American Journal of Physiology. Renal Physiology·Defang ChenMei Feng
Jul 3, 2021·International Journal of Molecular Sciences·Bastian AmendWilhelm K Aicher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

© 2021 Meta ULC. All rights reserved