Abstract
Lazaroid, an inhibitor of iron-mediated lipid peroxidation, has been shown to reduce free radical-mediated injury after ischemia and reperfusion. We thus examined the efficacy of pretreatment with lazaroid (U74500A) in enhancing functional recovery after 24-hr heart preservation. An isolated rabbit heart model perfused with the blood from a support rabbit was used. Before preservation, either U74500A (4 mg/kg, group L; n = 6) or solvent (group S; n = 7) was given to the donor rabbit. After 24-hr preservation with UW solution at 0 degrees C, all hearts were perfused with cross-circulated blood for 60 min with the Langendorff mode followed by 40 min of the working mode. In group S, ventricular fibrillation (Vf) after reperfusion was observed in all hearts, whereas no Vf was observed in the U74500A-pretreated group. In group L, the serum creatine phosphokinase; its isozyme, troponin-T; and serum lipid peroxide levels after 10 min of reperfusion were all significantly (P < 0.05) lower than those in group S. The Frank-Starling curve (indicating the left atrial pressure-aortic flow relationship) showed a significant left and upward shift in group L compared with that in group S (P < 0.0001). The heart pretreated with U74500A showed l...Continue Reading
References
Aug 1, 1992·Journal of Cardiovascular Pharmacology·F P CarreaL D Horwitz
Jan 1, 1992·Annals of Neurology·E D Hall
May 11, 1992·Transplantation·W A KillingerG Johnson
Jul 1, 1992·Circulation·M R Johnson
Feb 1, 1990·Journal of Cardiovascular Pharmacology·H H HolzgrefeJ K Gibson
Jul 1, 1990·The American Journal of Physiology·G SalviatiS Pierobon-Bormioli
Feb 3, 1989·JAMA : the Journal of the American Medical Association·S TodoT E Starzl
Jul 1, 1989·Circulation Research·D J HearseM Bernier
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Aug 1, 1988·Transplantation·R J PloegF O Belzer
Jan 1, 1987·Transplantation·J A WahlbergF O Belzer
Jul 1, 1987·Cardiovascular Research·S F BadylakC F Babbs
Oct 1, 1983·Journal of Molecular and Cellular Cardiology·P S RaoH S Mueller
Mar 1, 1984·Circulation Research·S R JollyB R Lucchesi
Oct 1, 1994·The Journal of Surgical Research·C R ShackletonP A Keown
Jan 1, 1994·Heart and Vessels·M MasudaW Flameng
Feb 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C A CosenzaL Makowka
Jul 6, 1993·Biochemical Pharmacology·Y WangM T Baker
Jan 1, 1993·Circulation·D B Pryor
Sep 1, 1993·Biochemical Pharmacology·T P RyanT W Petry
Citations
Feb 1, 1997·Transplantation Proceedings·J M Grinyó
Feb 25, 1998·Transplantation Proceedings·T TakahashiY Morishita
Dec 5, 1998·Transplantation Proceedings·T TakahashiY Morishita
May 5, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·T TakahashiY Morishita
Dec 30, 1998·Transplantation·J H FischerE Rainer de Vivie
Dec 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Toshinaga OzekiRobert S Poston
Jun 29, 2000·Scandinavian Cardiovascular Journal : SCJ·K KuwakiT Abe
Feb 1, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Noriko BokuShigeki Morita
Oct 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·Y TanoueH Yasui
Dec 21, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Noriyoshi KajiharaShigeki Morita
Jan 6, 1999·The Annals of Thoracic Surgery·T NishidaH Yasui
Oct 6, 2005·Biochemical and Biophysical Research Communications·Koshiro MonzenRyozo Nagai
Dec 15, 1996·Transplantation·A SalahudeenH Barber
Feb 10, 1998·Free Radical Research·G ZeltcerM Chevion
Feb 18, 2003·American Journal of Respiratory and Critical Care Medicine·Marc de PerrotShaf Keshavjee
May 13, 2003·Renal Failure·Hitchintan KaurKanwaljit Chopra
Sep 13, 2003·Circulation·Noriyoshi KajiharaHisataka Yasui