The effect of lead on bone mineral properties from female adult C57/BL6 mice.

Bone
A U MonirT L Dowd

Abstract

Lead toxicity is a significant problem in the U.S. with elevated blood lead levels being highest among very young children and older adults >50 years old. Bone is the major reservoir of body lead, accounting for 75% in children and 90% in adults. Very little is known about the effect of lead on bone mineral properties in adults. We investigated the effect of lead on the femora from adult, 6 month old female C57/BL6 mice who were administered lead in the drinking water (250 ppm, blood lead 33 μg/dL) for 4 months. Bone mineral properties were examined using Fourier Transform Infrared Microscopy (FTIRM), quantitative microcomputed tomography (microCT) and whole bone mechanical testing. Lead significantly decreased the bone mineral density in the cortical and proximal cancellous bone and increased the marrow area in the cortical bone with microCT. Whole bone three-point bending showed a trend of decreased maximum and failure moments in the lead treated bones compared to controls. Lead significantly decreased the mineral/matrix ratio, collagen maturity and crystallinity in the trabecular bone as measured by FTIRM. In the cortical bone lead significantly decreased collagen maturity and bone crystal size by FTIRM. In contrast to cell ...Continue Reading

References

May 1, 1975·British Journal of Industrial Medicine·P S Barry
Dec 1, 1992·Toxicology Letters·S Skerfving, U Nilsson
Jan 1, 1992·Gerontology·H R Massie, V R Aiello
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·F A SchanneJ F Rosen
Feb 1, 1981·British Journal of Industrial Medicine·P S Barry
Feb 1, 1994·Calcified Tissue International·T MiyaharaK Yokoyama
Sep 15, 1995·The Biochemical Journal·L KnottA J Bailey
Mar 31, 1995·Toxicology·T MiyaharaH Odake
Oct 1, 1994·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·C GamblinC E Webber
May 1, 1994·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J D Hamilton, E J O'Flaherty
Nov 3, 1998·Environmental Health Perspectives·J L PirkleD C Paschal
Aug 7, 1999·Mineral and Electrolyte Metabolism·H E GruberH C Gonick
May 8, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GarneroJ M Delaissé
Oct 11, 2005·Journal of Cellular Biochemistry·Eric C SealesJay M McDonald
Oct 18, 2005·Journal of Cellular Biochemistry·Majd Zayzafoon
Jan 30, 2007·Bone·L V HaleA G Geiser
Apr 16, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Naila KhalilSteven R Cummings
May 10, 2008·Calcified Tissue International·S A J LloydTed A Bateman

❮ Previous
Next ❯

Citations

Oct 23, 2012·Environmental Health Perspectives·Eric E BeierJ Edward Puzas
Nov 30, 2013·Biological Trace Element Research·Cecilie DahlUNKNOWN Norwegian Epidemiologic Osteoporosis Study (NOREPOS) Core Research Group
Apr 13, 2013·Indian Journal of Occupational and Environmental Medicine·Vijaya Prakash Krishnan MuthaiahJayaraman Gopalsamy
Mar 30, 2012·Bulletin of Environmental Contamination and Toxicology·María Inés ContiMaría del Pilar Martínez
Nov 1, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Eric E BeierJ Edward Puzas
Oct 1, 2015·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ching Ming LeeMaría Pilar Martínez
Jul 22, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Eric E BeierJ Edward Puzas
Apr 11, 2015·Environmental Health Perspectives·Eric E BeierRobert A Mooney
Aug 26, 2015·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Michael DermiencePhilippe Goyens
Feb 5, 2013·Chemico-biological Interactions·Elżbieta Kupraszewicz, Malgorzata M Brzóska
Jul 15, 2015·Journal of Exposure Science & Environmental Epidemiology·Tsung-Lin TsaiShu-Li Wang
Apr 29, 2014·Bone·José A A BritoLuísa L Gonçalves
Mar 30, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yu ZhangJingjing Jiao
Jul 31, 2013·The Science of the Total Environment·Pedro Álvarez-LloretRafael Mateo
Aug 8, 2012·Therapeutic Advances in Musculoskeletal Disease·Christian M Girgis, Markus J Seibel
Mar 3, 2018·Nutrients·Abdur RahmanKhalid M Khan
Apr 24, 2020·Orthopedics·Amy L MeyersRyan A Nelson
Jan 25, 2019·Journal of Toxicology·Juliana Rodríguez, Patricia Mónica Mandalunis
Aug 14, 2019·Biological Trace Element Research·Zhijie ShengZengli Zhang
May 10, 2018·Biological Trace Element Research·Shanshan QiHai Jiang
Dec 8, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ab Latif WaniMohammad Afzal
May 28, 2021·Journal of Biochemical and Molecular Toxicology·Hoda Samir AglanDawit Tesfaye

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Environmental Health Perspectives
J G PoundsJ F Rosen
Environmental Health Perspectives
R A GoyerJ G Pounds
Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Dennis A ChakkalakalTerrence M Donohue
© 2021 Meta ULC. All rights reserved