PMID: 6982258Oct 1, 1982Paper

The effect of lentinan on production of interleukin-1 by human monocytes

Immunopharmacology
J P FruehaufR B Herberman

Abstract

Activated human monocytes produce a monokine, interleukin-1 (IL-1) which can amplify the immune response by inducing antigen specific T cells to elaborate T cell growth factor, or interleukin-2, which in turn causes T cells to proliferate. The immune adjuvant lentinan has been shown in this study to augment IL-1 production by human monocytes. Stimulation of IL-1 by lentinan was seen as early as 5 hr, with some effect as late as 60 hr. Optimal effects were seen with very low concentrations, around 0.1 micrograms/ml. Lentinan was also able to stimulate IL-1 production by the leukemic cell line, K-562. The data reported here suggest that the previously reported adjuvant effects of lentinan may in part be mediated via its ability to stimulate IL-1 production.

References

Jan 1, 1976·Annals of the New York Academy of Sciences·P W MansellJ W Proctor
Dec 15, 1979·International Journal of Cancer. Journal International Du Cancer·N R Di LuzioA Kitahama
Oct 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·T B StromJ P Merrill
Jan 1, 1981·Immunological Reviews·A L GlasebrookF W Fitch
Jan 1, 1980·Immunological Reviews·K O Grönvik, J Andersson
Jun 1, 1980·The Journal of Experimental Medicine·K A SmithM F Favata
Oct 23, 1980·The New England Journal of Medicine·E R Unanue
Sep 25, 1981·Science·J Dausset
Feb 14, 1980·Nature·E L LarssonA Coutinho
Jan 1, 1980·Journal of Immunological Methods·D TaramelliL Varesio
Apr 1, 1981·Proceedings of the Society for Experimental Biology and Medicine·B B LozzioA S Feliu
Jan 1, 1981·Bio Systems·E Mitrani
Aug 1, 1980·The Journal of Experimental Medicine·W A ScottZ A Cohn

❮ Previous
Next ❯

Citations

Jan 1, 1993·Cancer Immunology, Immunotherapy : CII·A LadányiK Lapis
Jan 1, 1985·Springer Seminars in Immunopathology·N R Di Luzio
May 10, 1985·Journal of Immunological Methods·J W LarrickM V Doyle
Jun 28, 1991·Mechanisms of Ageing and Development·P Dutartre, M Pascal
Jan 1, 1986·International Journal of Immunopharmacology·T SugaG Chihara
Jan 1, 1988·International Journal of Immunopharmacology·J F JeanninF Martin
Jan 1, 1990·International Journal of Immunopharmacology·I SuzukiT Yadomae
Jan 1, 1991·International Journal of Immunopharmacology·Y Y MaedaH Yonekawa
Jun 1, 1996·International Journal of Immunopharmacology·C KerékgyártóJ Fachet
Apr 25, 1997·Early Human Development·R Inés BarañaoE Polak de Fried
Jan 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A T IchikiC B Lozzio
May 25, 2013·Journal of Clinical Biochemistry and Nutrition·Masashi Mizuno, Yosuke Nishitani
Oct 8, 2009·Bioscience, Biotechnology, and Biochemistry·Masashi MizunoKazuki Kanazawa
Jan 24, 2006·International Immunopharmacology·Igor A Schepetkin, Mark T Quinn
Jan 1, 1994·Cancer Investigation·N A ChasseingL Rumi
May 10, 2016·Burns : Journal of the International Society for Burn Injuries·Shou-Xing WangYong Li
Sep 17, 2002·The American Journal of Chinese Medicine·Tsutomu NakadaToshihiko Hanawa
Sep 22, 2010·Journal of Applied Microbiology·J S Rodríguez-ZavalaR Moreno-Sánchez
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·K KayserH U Burkhardt
Aug 13, 2011·Journal of Bioenergetics and Biomembranes·Belem Yoval-SánchezJosé S Rodríguez-Zavala
Sep 19, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Annalisa MarucaFrancesco Ortuso

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.