The effect of leptin on maturation of the ovarian compartments of albino rats: an ultrastructural and histological study

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Mona A A ElshafieAyman A A Ewies

Abstract

Leptin serves as a signal to the central nervous system with information on the critical amount of adipose tissue stores that is necessary for activation of the hypothalamic-pituitary-ovarian axis. To document the histological and ultrastructural changes that occur in the ovarian follicles of immature albino rats treated with leptin when compared with controls. Furthermore, the endometrial histological and immunohistochemical, and vaginal cytological changes suggestive of ovulation were assessed. The study was carried out on 50 immature female albino rats aged 22 days; 24 of them were injected with 5 microg leptin daily and 26 rats were taken as controls. Vaginal smears were taken daily, three animals were sacrificed every 2-4 days from each group, ovaries and uteri were dissected and specimens were prepared for electron microscopic, histological and/or immunohistochemical assessment. The research project was approved by The Histology Department Committee of Alexandria Medical School, which is licensed for animal care and use. Electron microscopic and histological examination confirmed the occurrence of maturational changes in various ovarian components from 26 days of age in leptin-treated rats, with ovulation occurring from t...Continue Reading

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Citations

Oct 30, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·N Zuckerman-LevinY Latzer
Aug 27, 2014·Rapid Communications in Mass Spectrometry : RCM·Kimberly L RobertsonJohn Krigbaum
Aug 2, 2014·International Endodontic Journal·J Martín-GonzálezJ J Segura-Egea
Oct 3, 2014·PLoS Neglected Tropical Diseases·Luis Fernando ChavesAzael Saldaña
Jan 22, 2015·Clinical Chemistry·Vanesa G Martinez, Lorraine O'Driscoll
Nov 11, 2010·Annals of the New York Academy of Sciences·Aaron J WeissJeffrey I Mechanick
Jul 17, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Petra Kanioková VeseláMilan Bayer
Oct 7, 2011·Cardiovascular Therapeutics·Tim R SullivanMarkus Herrmann
Feb 12, 2010·The Journal of Clinical Endocrinology and Metabolism·Xiumei HongXiaobin Wang
Apr 16, 2013·Endocrinology·Lalita WattanachanyaRobert A Nissenson

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