The effect of leptin on the ventilatory responseto hyperoxia

Experimental Lung Research
Harald GroebenClarke G Tankersley

Abstract

Leptin-deficient mice show a blunted response to hypercapnia explained by central nervous system effects. The impact of leptin on peripheral chemoreceptor function is unclear. Therefore, 9 mutant (ob/ob) and 9 wild-type (+/+) mice were exposed to room air or 100% oxygen and respiratory rate (RR) and tidal volume (Vt) were measured. Subsequently, ob/ob mice received either leptin or vehicle and measurements were repeated. Compared to baseline, for +/+ mice, RR decreased significantly by 9.4% +/- 3.0% (means +/- SD), whereas Vt remained unchanged. Transition from normoxia to hyperoxia did not change RR and Vt in untreated ob/ob mice, whereas after leptin treatment, RR and Vt decreased significantly. Leptin deficiency abolishes the response to hyperoxia, which is restored by leptin replacement. Thus, leptin seems to be influential for a competent peripheral chemoreceptor function.

References

Sep 1, 1988·Respiration Physiology·J L Carroll, M A Bureau
Feb 1, 1988·Journal of Applied Physiology·E B OlsonJ A Dempsey
Sep 1, 1971·Journal of Applied Physiology·G E Bisgard, J H Vogel
Jul 28, 1995·Science·M A PelleymounterF Collins
Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer
Sep 1, 1996·The Journal of Clinical Investigation·M W SchwartzD G Baskin
Aug 1, 1996·Journal of Applied Physiology·C TankersleyP Smith
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·H FeiJ M Friedman
Mar 21, 1998·Nature Genetics·A StrobelA D Strosberg
Apr 1, 1999·Canadian Journal of Physiology and Pharmacology·G EnhorningI Vargas
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·C P O'donnellP L Smith
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·R FaggioniG Fantuzzi
Jun 13, 2000·Advances in Experimental Medicine and Biology·D D Kline, N R Prabhakar
Jun 16, 2001·Journal of Applied Physiology·J R RodmanC A Smith
Sep 18, 2002·Journal of Applied Physiology·Lennart K A LundbladJason H T Bates
Jun 24, 1963·Annals of the New York Academy of Sciences·P DEJOURS
Oct 28, 2003·Journal of Applied Physiology·Vsevolod Y PolotskyChristopher P O'Donnell

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Citations

Nov 3, 2010·Respiratory Research·Foteini MalliZoe Daniil
Jun 28, 2011·Expert Review of Respiratory Medicine·Riva Tauman, David Gozal
Nov 14, 2006·Paediatric Respiratory Reviews·Riva Tauman, David Gozal
Apr 21, 2012·International Journal of Peptides·Diana R Engineer, Jose M Garcia
Feb 22, 2011·Brain Research·Andrea PorzionatoRaffaele De Caro
Aug 7, 2020·International Journal of Molecular Sciences·Joana F SacramentoSilvia V Conde
Feb 12, 2021·Physiological Reviews·Rodrigo IturriagaVirend K Somers

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