The effect of letrozole versus artificial hormonal endometrial preparation on pregnancy outcome after frozen-thawed embryos transfer cycles: a randomized clinical trial.

Reproductive Biology and Endocrinology : RB&E
Azadeh Hosseini-NajarkolaeiEnsieh Salehi

Abstract

Considering that clinical trial studies are limited in polycystic ovary syndrome (PCOS) patients, and there is no consensus on an optimum endometrial preparation protocol for frozen embryo transfer (FET), the present study was designed as a randomized clinical trial to compare the reproductive outcomes following stimulated cycles with letrozole plus human menopausal gonadotropin (HMG) for endometrial preparation compared with routine AC-FET. This randomized controlled trial was carried out on infertile PCOS patients who underwent IVF/ICSI and FET cycles in Arash Women's Hospital affiliated to Tehran University of Medical Sciences between September 2018 and January 2020. PCOS diagnosis was based on the Rotterdam criteria. Eligible patients were randomly allocated into two groups: stimulated cycle with letrozole plus (HMG) (intervention group) and routine artificial hormonal endometrial preparation (control group). One hundred seventy-seven infertile patients were recruited for participation in the study. Of these, 57 women were excluded due to non-eligibility for entering the study, and a total of 120 patients were randomly assigned to two study groups. After follow up, the cycle outcomes of 57 patients in the intervention group...Continue Reading

References

Sep 21, 2006·Reproductive Biomedicine Online·Kristen Page WrightFrancois Olivennes
Jan 17, 2012·Human Reproduction·Paul B MillerBruce A Lessey
Oct 16, 2012·Fertility and Sterility·Juan A Garcia-Velasco
Oct 15, 2013·Archives of Gynecology and Obstetrics·Song-jun LiGuang-shi Tao
Nov 26, 2015·Clinics·Anderson Sanches MeloPaula Andrea Navarro
Apr 30, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Caroline JouanMichelle Nisolle
Jul 5, 2017·The Cochrane Database of Systematic Reviews·Tarek GhobaraReuben Olugbenga Ayeleke
May 28, 2019·Fertility and Sterility·Jie ZhangYanping Kuang
Nov 11, 2019·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Maëliss PeignéSylvie Epelboin

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Methods Mentioned

BETA
pregnancy test
contraception
ubiquitination

Software Mentioned

Statistical Package for Social Sciences ( SPSS

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