PMID: 7018731Jan 1, 1981Paper

The effect of leucine on plasma insulin following endotoxin shock in the rat

Circulatory Shock
R D GoldfarbJ Eisenman

Abstract

We have previously documented the ability of exogenous L-leucine to accelerate the endotoxin shock syndrome. In this report we have tested the hypothesis that the mechanism for this action of leucine was via an induction of pancreatic insulin hypersecretion. Pentobarbital-anesthetized rats were injected with 1 mg/100 gm S. enteritidis endotoxin (LD90) or vehicle and infused with either Krebs Henseleit vehicle or 0.153 M leucine to a dose of 7.6 mmole/kg. Following leucine administration, plasma concentrations of leucine decayed at an exponential rate in both endotoxin-treated and sham-treated groups. The extrapolated initial leucine concentration in the endotoxin-treated rats was significantly higher than the sham rats, indicating a lower circulating blood volume in the endotoxin-treated group. In the vehicle and endotoxin-treated group, insulin levels exhibited a biphasic response, significantly lower at 30 minutes and significantly higher at three hours. In the leucine- and endotoxin-treated groups, insulin levels were markedly higher 0.5, 2, and 3 hours after leucine infusion. In the two non-endotoxin treated groups, no significant changes in insulin levels were noted after infusion. Therefore, the shock accelerating action ...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.