PMID: 466049Jul 1, 1979Paper

The effect of levamisole on postoperative immunosuppression

The British Journal of Surgery
R WindleP R Bell


Cell mediated immunity was studied before and after surgery in patients with colorectal cancer. Thymus-derived (T) lymphocytes were enumerated and their non-specific activity was measured by assessing phytohaemagglutinin (PHA)-induced blastogenesis. Specific T lymphocyte activity was measured by leucocyte migration inhibition in response to purified protein derivative of tuberculin (PPD) and autochthonous tumour extract. One group of patients received levamisole postoperatively and the other group consisted of controls. There was a more rapid return to preoperative levels of leucocyte migration inhibition to both antigens by the levamisole group. However, levamisole administration had only a marginal effect on the postoperative depression of cell counts and did not restore depressed lymphoblast transformation.


Jan 31, 1976·Lancet·A F RojasA J Olivari
Jul 30, 1977·Lancet·K M GoebelF Neurath
Jan 1, 1975·Archives of Virology·R CappelL Thiry
Feb 1, 1977·Cancer·S A Wilkins, Z L Olkowski
Sep 1, 1976·The Journal of Surgical Research·G C MillerR V Pierre
Jan 9, 1971·Lancet·S K ParkW S Blakemore
Aug 16, 1973·The New England Journal of Medicine·D TripodiJ Brugmans
Feb 1, 1967·Acta Medica Scandinavica·M Soborg, G Bendixen

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Oct 1, 1985·Klinische Wochenschrift·J A SmithJ N Norman
May 1, 1983·The Japanese Journal of Surgery·S MiyazakiH Tsuji
Apr 1, 1992·International Journal of Immunopharmacology·W K Amery, J P Bruynseels
Jul 1, 1993·Postgraduate Medicine·Robert Sexe, Brent W Miedema

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