The effect of levonorgestrel administered in large doses at different stages of the cycle on ovarian function and endometrial morphology

Contraception
B M LandgrenY E Shi

Abstract

In a pharmacokinetic study, levonorgestrel (L-NOG) 0.75 mg was administered orally to 10 swedish women in the early follicular phase of the menstrual cycle. L-NOG levels were measured after L-NOG administration. A peak level of 16 nmol/l was reached after 2 hours, T 1/2 was estimated to be 14.5 hours (8.5-18.5) in the 24-48-hour interval after dosing. Seventy-two women (in Stockholm, Bombay and Shanghai) were assigned to 4 treatment groups and studied during a control cycle, a treatment cycle and a posttreatment cycle when 0.75 mg L-NOG was administered orally for 4 days in the follicular phase, periovulatory period or luteal phase. Peripheral blood was drawn 3 times weekly during the entire study for the assay of estradiol and progesterone. In 22 women in Stockholm, an endometrial biopsy was obtained on cycle day 20-22 in all 3 cycles studied. When L-NOG was administered on periovulatory days 9, 11, 13, and 15, 3 women showed follicular activity only, 7 exhibited follicular activity followed by insufficient luteal function and 7 women ovulated normally. When L-NOG was administered on periovulatory days 11, 12, 16 and 19, 7 women ovulated during treatment, 6 women exhibited follicular activity followed by insufficient luteal fu...Continue Reading

References

Nov 1, 1976·Contraception·E WeinerE D Johansson
Jan 1, 1975·Contraception·J SponaW H Schneider
May 1, 1980·Acta Endocrinologica·B M LandgrenE Diczfalusy

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Citations

Nov 16, 1999·American Journal of Obstetrics and Gynecology·R RiveraD Grimes
Dec 25, 2002·Contraception·William S B YeungPak-chung Ho
Jul 9, 2002·Obstetrics and Gynecology·Lena MarionsKristina Gemzell Danielsson
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Nov 20, 2014·Pharmacoepidemiology and Drug Safety·Alfonso CarvajalLuis García Sevillano
Jan 27, 2010·Pharmacotherapy·Vivian W Y LeungJudith A Soon
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Dec 2, 2005·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·C BastianelliG Benagiano
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Sep 10, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Mayel ChirinosFernando Larrea
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Sep 9, 2005·Pediatrics·UNKNOWN American Academy of Pediatrics Committee on Adolescence
Nov 28, 2012·Pediatrics·UNKNOWN Committee On Adolescence

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