PMID: 7036105Jan 1, 1981Paper

The effect of LHRH antagonist analogs and an antibody to LHRH on mating behavior in female rats

Peptides
C A DudleyR L Moss

Abstract

The action of two antagonist analogs and an antibody to luteinizing hormone-releasing hormone (LHRH) on sexual receptivity was studied in avariectomized, estrogen-progesterone primed female rats. Small amounts of each LHRH substance or saline was infused through a cannula positioned in either the third ventricle or arcuate-ventromedial (ARC-VMH) area of the hypothalamus. Infusions were carried out at the time of progesterone priming, which was 42 hrs post-estrogen treatment, and sexual receptivity, as denoted by the lordosis-to-mount ratio, was measured six hrs later. One antagonist analog, [D-pGlu1, D-Phe2, D-Trp3,6]-LHRH[1], had little or no effect on sexual receptivity when tested in either site. Similarly, an antibody to LHRH, tested only in the ARC-VMH, had no observable effect on lordotic behavior. However, the second and the most potent antagonist analog, [Ac-dehydro-Pro1, pCl-D-Phe2, D-Trp3,6]-LHRH[2], produced a marked and significant decrement in lordotic behavior when infused into either the third ventricle or ARC-VMH. These results suggest that this potent and long-acting, competitive antagonist analog of LHRH prevented endogenous LHRH from exerting its normal role in the induction of sexual receptivity and provide ...Continue Reading

References

Jun 1, 1979·Journal of Comparative and Physiological Psychology·M M Foreman, R L Moss
Jan 1, 1976·Endocrine Research Communications·J A Vilchez-MartinezA V Schally
Dec 1, 1980·Pharmacology, Biochemistry, and Behavior·A J KastinJ E Zadina

❮ Previous
Next ❯

Citations

Jan 1, 1986·Physiology & Behavior·T R Saito, H Moltz
Apr 1, 1984·Pharmacology, Biochemistry, and Behavior·R L CooperM Linnoila
Dec 1, 1988·Pharmacology, Biochemistry, and Behavior·C BeyerP Gómora
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·E M Kostarczyk
Dec 1, 1986·Molecular and Cellular Endocrinology·J T PanD W Pfaff
Dec 3, 2013·Pharmacology, Biochemistry, and Behavior·J G VeeningP O Gerrits
Jul 10, 1995·The Journal of Comparative Neurology·E F RissmanJ R Millam
Jan 1, 1986·Annals of the New York Academy of Sciences·C Beyer, G González-Mariscal
Jun 1, 1991·Molecular and Cellular Neurosciences·T L Thompson, R L Moss
Sep 24, 2005·Endocrinology·Deborah K BarnettDavid H Abbott
May 26, 1999·Nihon Ika Daigaku zasshi·S Daikoku

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.