Abstract
Linagliptin is a new dipeptidyl peptidase-4 inhibitor recently approved for use in the USA. The objective of this systematic review and meta-analysis was to assess effect of linagliptin on glycaemic control, biomarkers and incidence of adverse events (AEs) in patients with type 2 diabetes mellitus. Five published and four unpublished randomized, clinical trials were identified from multiple databases. Qualitative assessments and quantitative analyses were performed. Nine studies included 4246 participants with 53% men, 59.4% Caucasians, 38.7% Asians, and age range 45-69 years. Linagliptin was given as monotherapy (vs. placebo) or combined with metformin (vs. metformin + placebo), sulphonylurea (vs. sulphonylurea + placebo) or pioglitazone (vs. pioglitazone + placebo). Linagliptin 5 mg/day for 12-24 weeks, significantly reduced haemoglobin A1c (HbA1c) (-0.63%, p < 0.00001), fasting plasma glucose (FPG) (-1.01 mmol/l, p < 0.00001) and improved disposition index (DI, product of insulin sensitivity and acute insulin secretion) (p = 0.0001). Linagliptin monotherapy was not more effective than metformin at reducing HbA1c or FPG. Similar proportion of patients in linagliptin and placebo groups reported AEs including upper respiratory ...Continue Reading
References
May 25, 2002·European Journal of Clinical Investigation·R N BergmanS E Kahn
May 31, 2003·BMJ : British Medical Journal·Joel LexchinOtavio Clark
Aug 21, 2003·JAMA : the Journal of the American Medical Association·Bodil Als-NielsenLise L Kjaergard
Oct 23, 2008·Diabetologia·D M NathanUNKNOWN European Association for the Study of Diabetes
Mar 27, 2009·The American Journal of the Medical Sciences·Daniel M RicheKrista D Riche
May 2, 2009·Diabetes Care·Alexander R Cobitz, Phil Ambery
Jul 23, 2009·BMJ : British Medical Journal·Alessandro LiberatiDavid Moher
Jan 21, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Stefan BlechKlaus Wagner
Jul 20, 2010·Clinical Therapeutics·Akiko SarashinaKlaus A Dugi
Nov 10, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·T ForstK A Dugi
Dec 1, 2010·Diabetes, Obesity & Metabolism·M-R TaskinenH-J Woerle
Jan 6, 2011·Diabetes, Obesity & Metabolism·S Del PratoK A Dugi
Jan 29, 2011·Diabetes Care·Marjolein J WillemenHubert G Leufkens
Feb 11, 2011·Diabetes/metabolism Research and Reviews·Matteo MonamiEdoardo Mannucci
Feb 16, 2011·Diabetes, Obesity & Metabolism·K EspositoD Giugliano
Feb 22, 2011·Gastroenterology·Michael ElashoffPeter C Butler
Mar 1, 2011·Diabetes, Obesity & Metabolism·T ForstK A Dugi
Mar 18, 2011·Diabetes, Obesity & Metabolism·R GomisK A Dugi
Jul 26, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·D R OwensH J Woerle
Oct 1, 2011·Diabetes, Obesity & Metabolism·K EspositoD Giugliano
May 29, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M MonamiE Mannucci
Sep 4, 2012·Clinical Therapeutics·Andrew J LewinHans-Juergen Woerle
Feb 14, 2013·Journal of Diabetes and Its Complications·Stefano Del PratoHans-Juergen Woerle
Mar 2, 2013·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Julio RosenstockHans-Jürgen Woerle
May 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Payal ShahKathrin Maedler
Citations
Nov 28, 2012·Advances in Therapy·Chrysi Koliaki, John Doupis
Sep 24, 2013·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Jaime A Davidson
Oct 5, 2012·Diabetes, Obesity & Metabolism·D Singh-FrancoJ McLaughlin-Middlekauff
Oct 5, 2012·Diabetes, Obesity & Metabolism·D R OwensH-J Woerle
Aug 24, 2012·Drugs·Emma D Deeks
Feb 5, 2013·Expert Opinion on Drug Metabolism & Toxicology·André J Scheen
Feb 21, 2013·Expert Opinion on Drug Safety·André J Scheen
Mar 16, 2016·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Solène Schirr-BonnansLaurent Molinier
Jul 16, 2015·Clinical and Experimental Pharmacology & Physiology·Xiao-Wu ChenShu-Feng Zhou
Feb 1, 2015·Clinical Pharmacokinetics·Silke RetlichAlexander Staab
May 21, 2015·Cardiovascular Diabetology·Julio RosenstockOdd Erik Johansen
Jul 13, 2014·Clinical Therapeutics·Michael LehrkeOdd Erik Johansen
Jan 21, 2016·Diabetes/metabolism Research and Reviews·Francesco GiorginoPaolo Pozzilli
Sep 23, 2016·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Han ChenGuoxin Zhang
Sep 21, 2016·PLoS Medicine·Su GolderGill Norman
Aug 16, 2016·SAGE Open Medicine·Devada Singh-FrancoEglis Tellez-Corrales
Mar 21, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Guillermo E Umpierrez, Luigi Meneghini
Jun 6, 2020·The Cochrane Database of Systematic Reviews·Filip GnesinBianca Hemmingsen
Jul 30, 2020·BMJ Open·Junice Yi Siu NgErik Wiebols
Oct 16, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jaime A Davidson
Jun 3, 2018·Acta Diabetologica·Juan LingKe-Hu Yang
May 20, 2018·Cardiovascular Diabetology·Fausto ChiazzaCesare Patrone
Sep 23, 2018·Acta Diabetologica·Juan LingKe-Hu Yang