PMID: 6107340Oct 1, 1980Paper

The effect of lipid-depletion on the kinetic properties of rat liver monoamine oxidase-B

The Journal of Pharmacy and Pharmacology
C J Fowler, L Oreland

Abstract

The extraction of lipids from rat liver mitochondrial membranes by 2-butanone treatment inhibited the activity of membrane-bound monoamine oxidase -A but not -B. For the -B form, the apparent Michaelis constants of the enzyme towards oxygen and the maximum molecular turnover numbers obtained when beta-phenethylamine and benzylamine were used as substrates were not significantly changed by the lipid-depletion procedure, but the values of the Michaelis constant towards benzylamine was significantly increased after lipid-depletion. The differential sensitivity of beta-phenethylamine and benzylamine oxidation to inhibition by Tris-HCl was not changed after lipid-depletion. The results are consistent with the hypothesis that the mitochondrial membrane lipids, while essential for the activity of the -A form of the enzyme in rat liver, play a more subtle modulatory role in the activity of the -B form.

References

Aug 15, 1976·Life Sciences·M D Houslay, K F Tipton
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Citations

Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H KinemuchiK Kamijo
Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·Y H SuhH Kinemuchi
Oct 19, 1993·Biochemical Pharmacology·K F Tipton, T P Singer
Jul 15, 1983·Archives of Biochemistry and Biophysics·L B Pearce, J A Roth
Nov 1, 1986·The Journal of Pharmacy and Pharmacology·S J Haque, M K Poddar
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ayman S BannagaRamesh P Arasaradnam
Mar 29, 1982·Life Sciences·A Schurr

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