The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease

Journal of Neurodegenerative Diseases
Antonietta FavaDomenico Bosco

Abstract

Diabetes mellitus (DM) is an important risk factor for Alzheimer's disease (AD). Most diabetic patients have insulin resistance (IR) that is associated with compensatory hyperinsulinemia, one of the mechanisms suggested for increased AD risk in patients with DM. Alpha-lipoic acid (ALA) is a disulfide molecule with antioxidant properties that has positive effects on glucose metabolism and IR. This study evaluated the effect of ALA treatment (600 mg/day) on cognitive performances in AD patients with and without DM. One hundred and twenty-six patients with AD were divided into two groups, according to DM presence (group A) or absence (group B). Cognitive functions were assessed by MMSE, Alzheimer's Disease Assessment Scale-cognitive (ADAS-Cog), Clinician's Interview-Based Impression of Severity (CIBIC), Clinical Dementia Rating (CDR), and Alzheimer's Disease Functional and Change Scale (ADFACS). IR was assessed by HOMA index. At the end of the study, MMSE scores showed a significant improvement in 43% patients of group A (26 subjects) and 23% of group B (15 subjects), compared to baseline (P = .001). Also ADAS-Cog, CIBIC, and ADFACS scores showed a significant improvement in group A versus group B. IR was higher in group A. Our st...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Apr 1, 1988·Journal of the American Geriatrics Society·M FismanJ Dupre
Nov 1, 1984·The American Journal of Psychiatry·W G RosenK L Davis
Aug 1, 1995·Free Radical Biology & Medicine·L PackerH J Tritschler
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Dec 11, 1999·Archives of General Psychiatry·S CraftR C Veith
Dec 22, 1999·Neurology·A OttM M Breteler
Oct 3, 2001·American Journal of Epidemiology·J A LuchsingerR Mayeux
Dec 14, 2002·Neuroscience and Biobehavioral Reviews·Norton W MilgramC W Cotman
Jan 30, 2004·Diabetes·Juliette JansonPeter C Butler
Feb 27, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·D ZieglerP A Low
May 12, 2004·Current Medicinal Chemistry·A R SmithT M Hagen
Oct 13, 2004·Neurology·Jose A LuchsingerRichard Mayeux
Sep 23, 2006·Pharmacology & Therapeutics·Lina HolmquistGerald Münch
Apr 26, 2007·Clinical Medicine & Research·Wee Shiong LimSuresh Sahadevan
Jan 23, 2009·Free Radical Research·Sandra L SiedlakGeorge Perry
Oct 20, 2009·Journal of the Neurological Sciences·Massimiliano PlastinoDomenico Bosco
Nov 3, 2009·Journal of Diabetes and Its Complications·Mohammed A KandeilEman T Mohammed
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Weiping Han, Cai Li

❮ Previous
Next ❯

Citations

Jul 13, 2016·Future Medicinal Chemistry·Martín EstradaMaría Isabel Rodríguez-Franco
Sep 27, 2018·Frontiers in Neuroscience·Jun-Lin LiuChuang Guo
Dec 31, 2019·Oxidative Medicine and Cellular Longevity·Sávio Monteiro Dos SantosMarta Chagas Monteiro
May 27, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mino R CairaBuntubonke Mzondo
Jul 3, 2021·International Journal of Molecular Sciences·Francesca Serena AbatematteoCarmen Abate
Aug 28, 2021·Life Sciences·Dapinder KaurSimona Bungau
Aug 31, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·R G EsinO R Esin
Sep 24, 2021·Journal of Neurochemistry·Md JakariaScott Ayton

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis

Software Mentioned

plus
CIBIC

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.