The effect of listening to music on human transcriptome

PeerJ
Chakravarthi KanduriIrma Järvelä

Abstract

Although brain imaging studies have demonstrated that listening to music alters human brain structure and function, the molecular mechanisms mediating those effects remain unknown. With the advent of genomics and bioinformatics approaches, these effects of music can now be studied in a more detailed fashion. To verify whether listening to classical music has any effect on human transcriptome, we performed genome-wide transcriptional profiling from the peripheral blood of participants after listening to classical music (n = 48), and after a control study without music exposure (n = 15). As musical experience is known to influence the responses to music, we compared the transcriptional responses of musically experienced and inexperienced participants separately with those of the controls. Comparisons were made based on two subphenotypes of musical experience: musical aptitude and music education. In musically experiencd participants, we observed the differential expression of 45 genes (27 up- and 18 down-regulated) and 97 genes (75 up- and 22 down-regulated) respectively based on subphenotype comparisons (rank product non-parametric statistics, pfp 0.05, >1.2-fold change over time across conditions). Gene ontological overrepresen...Continue Reading

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Citations

Dec 22, 2016·Journal of Psychosocial Nursing and Mental Health Services·Robert H Howland
Dec 23, 2016·Scientific Reports·Jaana OikkonenChakravarthi Kanduri
Mar 24, 2018·Annals of the New York Academy of Sciences·Irma Järvelä
Apr 11, 2018·Integrative Cancer Therapies·Tereza Raquel Alcântara-SilvaLeonardo Ribeiro Soares
Feb 26, 2016·PloS One·Jaana OikkonenIrma Järvelä
Nov 23, 2017·Frontiers in Psychology·Andrea Ravignani, Guy Madison
Sep 2, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Preethy Sasidharan NairIrma Järvelä
Sep 27, 2018·Frontiers in Medicine·Amy Clements-Cortes, Lee Bartel
Jun 14, 2020·Journal of Applied Genetics·Krzysztof Szyfter, Michał P Witt
Apr 9, 2019·PeerJ·Preethy Sasidharan NairIrma Järvelä
Jun 3, 2021·International Journal of Molecular Sciences·Livia BeccaceceDonata Luiselli
Aug 4, 2021·Genes, Brain, and Behavior·Sophie von MertenDiethard Tautz

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Methods Mentioned

BETA
sumoylation

Software Mentioned

RankProd Bioconductor
SAM
GeneTrail
R package
genefilter
Lumi
RankProd

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